Amantadine Hydrochloride

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Brand Names
Symadine, Symmetrel

Amantadine hydrochloride Information

Amantadine is.Amantadine can be used to treat and prevent influenza A . Amantadine may not be successful during each flu season due to certain strains of influenza virus might be resistant to the medication.Amantadine should not be used instead of obtaining an annual flu shot. The Centers for Disease Control recommends an annual flu shot to help protect you each year.Amantadine is also used to treat Parkinson’s disease and “Parkinson-like” symptoms such as stiffness and shaking that could be caused by the usage of particular drugs.Amantadine may be used for purposes not listed in this medication guide.

Used for treatment: Cerebral Arteriosclerosis, Chorea, Drug-induced Extrapyramidal Side Effects, Influenza A Virus Infection, Lethargy, Parkinson's Disease, Post-encephalitic Parkinsonism

The mechanism of its own antiparkinsonic effect isn’t fully understood, but it appears to be releasing dopamine in the nerve endings of the brain cells, together with stimulation of norepinephrine reaction. It also has NMDA receptor antagonistic effects. The antiviral mechanism appears to be unrelated. The drug interferes with a viral protein, M2 (a ion channel), which will be needed for the viral particle to become “uncoated” when it is taken in the cell by endocytosis.

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How to use amantadine hydrochloride

Follow all directions on your prescription label. Do not take this medication in smaller or bigger quantities or for longer than advised. Measure medication with the syringe supplied, or using a special dose-measuring spoon or medicine cup. If you do not own a dose-measuring device, ask your pharmacist for one. If you take amantadine to treat influenza A, then start taking the medication after flu symptoms begin.

Keep taking amantadine. Your symptoms may improve before the infection is totally cleared. If you take this medication for Parkinson symptoms, your physician may change your dose. Amantadine will not take care of an infection brought on by bacteria. Call your doctor if your symptoms don’t improve, or if you have a fever with a headache, cough, skin rash, or other symptoms that are new.

Should you choose amantadine for Parkinson signs: you shouldn’t quit using amantadine suddenly or your illness may become worse. Store at room temperature away from moisture, heat, and light.

Side Effects

  • diarrhea
  • dizziness upon rising from a sitting position
  • sleepiness
  • abnormal dreams
  • anorexia
  • insomnia
  • constipation
  • fatigue
  • swelling of arms, legs, or feet
  • loss of muscle coordination/control
  • dry nose
  • anxiety and irritability
  • nervousness
  • dry mouth
  • nausea
  • confusion
  • headache
  • depression
  • lightheadedness
  • a netlike pattern of reddish-blue skin discoloration, usually on the legs
  • hallucinations


Amantadine adds to the sedating effects of alcohol and other sedating drugs such as: The benzodiazepine class of anti-anxiety medications, for example: diazepam (Valium) lorazepam (Ativan) clonazepam (Klonopin) alprazolam (Xanax, Xanax XR, Niravam) zolpidem (Ambien, Ambien CR, Zolpimist, Edluar) The tricyclic class of antidepressants, for instance: amitriptyline (Elavil, Endep) imipramine (Tofranil, Tofranil-PM) desipramine (Norpramin) dicyclomine Certain antihistamines, for example: diphenhydramine (Benadryl) hydroxyzine (Vistaril, Atarax) clemastine Opiate agonists, for example: hydromorphone hydrochloride hydrocodone/acetaminophen (Vicodin, Vicodin ES, Lorcet, Lorcet Plus, Norco) oxycodone and acetaminophen (Percocet, Roxicet, Tylox, Oxycet) codeine Certain antihypertensive medications, such as: clonidine (Catapres, Catapres-TTS, Jenloga) propranolol Such mixtures can cause dizziness, confusion, lightheadedness, fainting, or dizziness upon standing .

Drugs which block the effects of dopamine should be avoided in men taking amantadine when amantadine is used for the treatment of Parkinson’s disease, since amantadine interrupts the activities of dopamine in the brain. Such drugs include haloperidol, metoclopramide, and phenothiazines, by way of example, thioridazine or triflupromazine.

The kidney’s capacity to eliminate amantadine can be reduced by the usage of triamterene or the diuretics hydrochlorothiazide with amantadine. This can lead in amantadine-associated toxicity and the bloodstream.

Parkinsons disease pharmacology – Soton Brain Hub