Amantadine Sulfate

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Brand Names
Symadine, Symmetrel

Amantadine sulfate Information

Amantadine is.Amantadine is used to treat and prevent influenza A . Due to strains of flu virus could be immune to the medicine, Amantadine might not be successful during each flu season.Amantadine should not be utilised in place of getting a flu shot. An annual flu shot to help protect you each year from new strains of flu virus is recommended by the Centers for Disease Control.Amantadine is also utilised to treat Parkinson’s disease and “Parkinson-like” outward symptoms such as stiffness and vibration that could possibly be caused by the use of certain drugs.Amantadine may be used for purposes not listed in this medication guide.

Used for treatment: Cerebral Arteriosclerosis, Chorea, Drug-induced Extrapyramidal Side Effects, Influenza A Virus Infection, Lethargy, Parkinson's Disease, Post-encephalitic Parkinsonism

The mechanism of its antiparkinsonic effect is not entirely known, but it seems to be releasing dopamine in the nerve endings of the brain tissues, together with stimulation of norepinephrine response. Additionally, it has NMDA receptor antagonistic effects. The antiviral mechanism appears to be unrelated. The drug interferes with a viral protein, M2 (an ion channel), which is needed for the viral particle to become “uncoated” when it’s taken in the cell by endocytosis.

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How to use amantadine sulfate

Follow all instructions. Do not take this medication in smaller or bigger amounts or for longer than advised. Measure medicine with an dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not own a dose-measuring device, ask your pharmacist for one. Should you choose amantadine to treat influenza A, then start taking the medicine after flu symptoms start.

Maintain taking amantadine. Your symptoms may improve before the infection is totally cleared. Your doctor may change your dose should you take this medicine for Parkinson symptoms. Amantadine will not take care of an infection. Call your health care provider if your symptoms do not improve, or if you’ve got a fever with cough, a headache, skin rash, or other symptoms. If you take amantadine for Parkinson signs: you shouldn’t stop using amantadine abruptly or your illness may become worse.

Store at room temperature away from heat, moisture, and lighting. Keep the bottle tightly closed when not in use.

Side Effects

  • diarrhea
  • dizziness upon rising from a sitting position
  • sleepiness
  • abnormal dreams
  • anorexia
  • insomnia
  • constipation
  • fatigue
  • swelling of arms, legs, or feet
  • loss of muscle coordination/control
  • dry nose
  • anxiety and irritability
  • nervousness
  • dry mouth
  • nausea
  • confusion
  • headache
  • depression
  • lightheadedness
  • a netlike pattern of reddish-blue skin discoloration, usually on the legs
  • hallucinations


Amantadine adds to the sedating effects of alcohol and other sedating medications such as: The benzodiazepine type of anti-anxiety drugs, such as: diazepam (Valium) lorazepam (Ativan) clonazepam (Klonopin) alprazolam (Xanax, Xanax XR, Niravam) zolpidem (Ambien, Ambien CR, Zolpimist, Edluar) The tricyclic class of antidepressants, for example: amitriptyline (Elavil, Endep) imipramine (Tofranil, Tofranil-PM) desipramine (Norpramin) dicyclomine Certain antihistamines, for example: diphenhydramine (Benadryl) hydroxyzine (Vistaril, Atarax) clemastine Opiate agonists, such as: hydromorphone hydrochloride hydrocodone/acetaminophen (Vicodin, Vicodin ES, Lorcet, Lorcet Plus, Norco) oxycodone and acetaminophen (Percocet, Roxicet, Tylox, Oxycet) codeine Certain antihypertensive medications, such as: clonidine (Catapres, Catapres-TTS, Jenloga) propranolol Such combinations can lead to dizziness, confusion, lightheadedness, fainting, or dizziness upon standing .

Since amantadine interrupts the actions of dopamine in the brain, drugs that block the effects of dopamine ought to be avoided in persons taking amantadine if amantadine is used for treating Parkinson’s disease. Such drugs include phenothiazines, and haloperidol, metoclopramide, by way of triflupromazine, thioridazine or instance. The usage of the diuretics hydrochlorothiazide or triamterene with amantadine can reduce the kidney’s ability to get rid of amantadine.

This may lead in amantadine-associated toxicity and the blood.

Influenza Treatment – Medications and Criteria for Treatment