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Brand Names
Symadine, Symmetrel

Amantadine Information

Amantadine is.Amantadine can be used to treat and protect against influenza A . Since strains of flu virus might be resistant to this medication Amantadine might not be effective during every flu season.Amantadine shouldn’t be used instead of getting an annual flu shot. An annual flu shot to help protect you each year from new strains of flu virus is recommended by the Centers for Disease Control.Amantadine is also utilised to treat Parkinson’s disease and “Parkinson-like” symptoms like stiffness and vibration which could possibly be brought on by the usage of particular drugs.Amantadine might also be used for purposes not listed in this medication guide.

Used for treatment: Cerebral Arteriosclerosis, Chorea, Drug-induced Extrapyramidal Side Effects, Influenza A Virus Infection, Lethargy, Parkinson's Disease, Post-encephalitic Parkinsonism

The mechanism of its own antiparkinsonic effect isn’t entirely understood, but it appears to be releasing dopamine in the nerve endings of their brain cells, together with stimulation of norepinephrine response. It also has NMDA receptor antagonistic effects. The antiviral mechanism appears to be unrelated. The drug interferes with a viral protein, M2 (a ion channel), which is needed for the viral particle to become “uncoated” when it’s taken inside the cell via endocytosis.

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How to use amantadine

Follow all directions. Do not take this medication in smaller or bigger quantities or for longer than advised. Measure medicine with all the syringe supplied, or using a special dose-measuring spoon or medicine cup. If you don’t own a dose-measuring device, ask your pharmacist for one. If you take amantadine to treat influenza A, then begin taking the medicine after flu symptoms start.

Keep taking amantadine. Your symptoms may improve before the infection is totally cleared. Your doctor may sometimes change your dose to be certain that you have the best outcomes, if you take this medicine for symptoms. Amantadine won’t treat an infection brought on by bacteria. Call your doctor if your symptoms don’t improve, or in case you’ve got a fever with a headache, cough, skin rash, or other symptoms.

You shouldn’t quit using amantadine abruptly: should you choose amantadine for symptoms or your illness may become worse. Store at room temperature away from moisture, heat, and lighting.

Side Effects

  • diarrhea
  • dizziness upon rising from a sitting position
  • sleepiness
  • abnormal dreams
  • anorexia
  • insomnia
  • constipation
  • fatigue
  • swelling of arms, legs, or feet
  • loss of muscle coordination/control
  • dry nose
  • anxiety and irritability
  • nervousness
  • dry mouth
  • nausea
  • confusion
  • headache
  • depression
  • lightheadedness
  • a netlike pattern of reddish-blue skin discoloration, usually on the legs
  • hallucinations


Amantadine increases the sedating effects of alcohol and other sedating medications such as: The benzodiazepine class of anti-anxiety drugs, such as: diazepam (Valium) lorazepam (Ativan) clonazepam (Klonopin) alprazolam (Xanax, Xanax XR, Niravam) zolpidem (Ambien, Ambien CR, Zolpimist, Edluar) The tricyclic class of antidepressants, for example: amitriptyline (Elavil, Endep) imipramine (Tofranil, Tofranil-PM) desipramine (Norpramin) dicyclomine Certain antihistamines, for example: diphenhydramine (Benadryl) hydroxyzine (Vistaril, Atarax) clemastine Opiate agonists, for example: hydromorphone hydrochloride hydrocodone/acetaminophen (Vicodin, Vicodin ES, Lorcet, Lorcet Plus, Norco) oxycodone and acetaminophen (Percocet, Roxicet, Tylox, Oxycet) codeine Certain antihypertensive medications, for example: clonidine (Catapres, Catapres-TTS, Jenloga) propranolol Such mixtures can cause dizziness, confusion, lightheadedness, fainting, or dizziness upon standing .

Since amantadine amplifies the actions of dopamine in the brain, drugs which block the effects of dopamine ought to be avoided in persons. Such drugs include phenothiazines, and haloperidol, metoclopramide, by way of triflupromazine, thioridazine or instance. The kidney’s ability can be reduced by the usage of the diuretics hydrochlorothiazide or triamterene with amantadine.

This can lead from the bloodstream along with amantadine-associated toxicity.