In order to buy amlodipine maleate online in UK you want a prescription. Our convenient service allows you to acquire a prescription and medicine without visiting a physician face-to-face.
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Amlodipine maleate Information
Amlodipine is a calcium channel blocker Which dilates Blood vessels and improves blood circulation. Amlodipine is used to treat chest pain And other ailments. Amlodipine can also be utilized in the treatment of hypertension . Blood pressure can reduce your chance of a stroke or heart attack.Amlodipine is for use in adults and kids who are at least 6 years old.Amlodipine may also be used for purposes not listed in this medication guide.
Amlodipine reduces nitric smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin subsequently binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key measure in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium reduces the contractile activity of arterial smooth muscle cells and results in vasodilation. The vasodilatory effects of amlodipine bring about an overall decrease in blood pressure. Amlodipine is a long-acting CCB which may be used as a treatment for mild to moderate essential hypertension and exertion-related angina (chronic stable angina). Another possible mechanism is that amlodipine inhibits vascular smooth muscle carbonic anhydrase I action causing cellular pH increases that might be involved in regulating intracelluar calcium influx through calcium channels.
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How to use amlodipine maleate
Follow all directions. Your dosage may sometimes change. Do not use this medicine in bigger or smaller amounts or for longer than advised. You might take amlodipine with or without meals. Take the medication at exactly the exact same time each day. Your blood pressure will need to get checked often. Your chest pain may become worse when your dose is slowly increased or if you begin taking amlodipine.
If your chest pain is either ongoing or severe call your physician. Keep using amlodipine even in the event that you are feeling well if you are being treated for high blood pressure. High blood pressure has no symptoms. You might need to use blood pressure medicine for the rest of your life. Your heart or hypertension condition may be treated with a mixture of drugs. Utilize instructed by your doctor.
Read the medication guide or individual instructions provided with every drug. Do not change your doses or stop taking some of your medications without your physician’s advice. This is particularly important if you take nitroglycerin. Amlodipine is a portion of a application of therapy that may include exercise diet, weight management, and medications. Follow your diet, medication, and exercise routines very closely.
Store at room temperature away from light, heat, and moisture.
Side Effects
- arrhythmia (irregular heartbeat)
- tiredness, extreme sleepiness
- stomach pain, nausea
- dizziness
- headache
- heart palpitations (very fast heartbeat)
- leg or ankle swelling
- flushing (hot or warm feeling in the face)
Interactions
Combining amlodipine with similar and sildenafil drugs can lead to cuts in blood pressure upon standing. Amlodipine significantly increases blood levels of simvastatin. The dose of simvastatin should be limited to 20 mg per day by patients taking amlodipine. Ketoconazole , itraconazole , ritonavir and other medications that are inhibitors of amlodipine inactivation in the liver increase blood levels of amlodipine, resulting in excess blood pressure decrease.