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Amlodipine Information
Amlodipine is Blood vessels and improves blood circulation. Amlodipine is used to treat chest discomfort And other conditions. Amlodipine is used as a treatment for hypertension . Blood pressure can decrease your chance of a stroke or heart attack.Amlodipine is for use in children and adults who are at least 6 years old.Amlodipine may also be used for purposes not listed in this medication guide.
Amlodipine decreases arterial smooth muscle contractility and following vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key measure in muscular contraction. Signal amplification is accomplished by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the primary influx of calcium reduces the contractile activity of arterial smooth muscle cells and results in vasodilation. The vasodilatory effects of amlodipine result in an overall decrease in blood pressure. Amlodipine is a long-acting CCB that may be used to treat mild to moderate essential hypertension and exertion-related angina (chronic stable angina). Another possible mechanism is that amlodipine inhibits vascular smooth muscle carbonic anhydrase I activity causing mobile pH increases that might be involved in regulating intracelluar calcium influx through calcium channels.
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How to use amlodipine
Follow all instructions. Your dosage may occasionally change. Do not use this medicine in bigger or smaller quantities or for longer than advised. You might take amlodipine with or without food. Take the medicine. Your blood pressure will have to be checked. Your chest pain may become worse if you start taking amlodipine or whenever your dose is raised. Call your physician if your chest pain is ongoing or acute.
If you are being treated for high blood pressure, then keep using amlodipine even in case you are feeling well. High blood pressure has no signs. You might have to use blood pressure medicine for the remainder of your life. Your hypertension or heart disease could be treated with a mix of drugs. Use instructed by your doctor. Read the medication guide or individual instructions provided with each drug.
Don’t change your doses or stop taking any of your medicines without the advice of your doctor. This is particularly important when you take nitroglycerin. Amlodipine is just a portion of a complete program of treatment which may also incorporate diet diet, weight control, and medicines.
Side Effects
- arrhythmia (irregular heartbeat)
- tiredness, extreme sleepiness
- stomach pain, nausea
- dizziness
- headache
- heart palpitations (very fast heartbeat)
- leg or ankle swelling
- flushing (hot or warm feeling in the face)
Interactions
Mixing amlodipine using similar and sildenafil drugs may lead upon standing. Amlodipine significantly increases blood levels of simvastatin. The dose of simvastatin ought to be limited to 20 mg daily by individuals. Ketoconazole , itraconazole , ritonavir and other medications that are powerful inhibitors of inactivation in the liver increase blood levels of amlodipine, resulting in excess blood pressure reduction.