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Caduet, Lipitor, Liptruzet
Atorvastatin calcium trihydrate Information
Atorvastatin is in a group of medications called HMG CoA reductase inhibitors, or “statins.” Atorvastatin reduces amounts of “bad” cholesterol And triglycerides from the bloodstream, while raising levels of “good” cholesterol. Atorvastatin can be used to treat hypertension, and to decrease the chance of stroke, heart attack, or other cardiovascular problems in individuals with coronary heart disease, type 2 diabetes, along with threat factors.Atorvastatin can be used in kids and adults who are at least 10 years older.Atorvastatin may also be used for purposes not listed in this medication guide.
Atorvastatin selectively and competitively inhibits the hepatic enzyme HMG-CoA reductase. As HMG-CoA reductase is responsible for converting HMG-CoA to mevalonate from the cholesterol biosynthesis pathway, this results in a subsequent reduction in hepatic cholesterol levels. Decreased hepatic cholesterol levels stimulates upregulation of hepatic LDL-C receptors that raises hepatic uptake of LDL-C and reduces serum LDL-C concentrations.
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How to use atorvastatin calcium trihydrate
Follow all instructions. Your physician may change your dose. Don’t use this medication in bigger or smaller amounts or for longer than suggested. Atorvastatin is usually taken once per day, with or without meals. Take the medication. Do not violate an atorvastatin tablet.
It might take up to 2 weeks ahead of your cholesterol levels grow, and you may need frequent blood tests. You might not observe some change in your symptoms, however bear using the medicine as directed.
Your blood work will help your physician determine to treat you with atorvastatin. Atorvastatin is a portion of an entire treatment program that may have diet, exercise, and weight management. Follow your physician’s instructions. Store at room temperature away from heat, moisture, and light.
Side Effects
- Muscle problems. Atorvastatin can cause serious muscle problems that can lead to kidney problems, including kidney failure. You have a higher chance for muscle problems if you are taking certain other medicines with atorvastatin.
- you feel more tired than usual
- your skin and whites of your eyes get yellow.
- hives
- muscle problems like weakness, tenderness, or pain that happen without a good reason, especially if you also have a fever or feel more tired than usual.
- passing brown or dark-colored urine.
- neck pain
- joint swelling
- yellowing of your skin or the whites of your eyes
- dark amber colored urine
- nausea and vomiting.
- allergic skin reactions.
- allergic reactions including swelling of the face, lips, tongue, and/or throat that may cause difficulty in breathing or swallowing which may require treatment right away.
- Liver problems. Your doctor should do blood tests to check your liver before you start taking atorvastatin and if you have symptoms of liver problems while you take atorvastatin. Call your doctor right away if you have the following symptoms of liver problems:
- feel tired or weak
- general feeling of discomfort (malaise)
- upper belly pain
- loss of appetite
- fever
- stomach pain.
Interactions
Decreased removal of Lipitor could increase levels of Lipitor and increase the risk of muscle fatigue. Lipitor shouldn’t be combined. Examples of these drugs includes: erythromycin, ketoconazole, itraconazole, clarithromycin, telithromycin, cyclosporine, nefazodone, and HIV protease inhibitors such as indinavir and ritonavir. Massive quantities of fruit juice also will increase blood levels of Lipitor and shouldn’t be taken. The risk of muscle fatigue may increase when combined with Lipitor.
Cyclosporine niacin gemfibrozil fenofibrate Lipitor increases also the concentration in blood of digoxin and warfarin’s impact. Patients taking warfarin or digoxin and Lipitor should be monitored carefully. Cholestyramine decreases the absorption of Lipitor. Lipitor must be granted four hours. Breakdown of Lipitor increases. To decrease the probability of the interaction both drugs should be provided at precisely the exact same time.
Lipitor should not be given following rifampin.