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Caduet, Lipitor, Liptruzet
Atorvastatin calcium Information
Atorvastatin is in a set of medications known as HMG CoA reductase inhibitors, or “statins.” Atorvastatin reduces levels of “bad” cholesterol And triglycerides in the blood, while increasing levels of “good” cholesterol . Atorvastatin is used to treat hypertension, and also to decrease the risk of stroke, heart attack, or other cardiovascular complications in individuals with coronary heart disease, type 2 diabetes, along with other risk variables.Atorvastatin can be used in kids and adults who are at least 10 years of age.Atorvastatin may also be used for purposes.
Atorvastatin selectively and competitively inhibits the hepatic enzyme HMG-CoA reductase. As HMG-CoA reductase is responsible for converting HMG-CoA to mevalonate from the cholesterol biosynthesis pathway, this ends in a subsequent decrease in hepatic cholesterol levels. Decreased hepatic cholesterol levels stimulates upregulation of hepatic LDL-C receptors that raises hepatic uptake of both LDL-C and reduces serum LDL-C concentrations.
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How to use atorvastatin calcium
Follow all directions. Your doctor may change your dose. Do not use this medicine in smaller or bigger amounts or for longer than suggested. Take the medicine. Before taking it, do not violate an atorvastatin tablet.
It may take as many as 2 months before your cholesterol levels improve, and you may need frequent blood tests.
You might not observe any change in your symptoms, however keep using the medicine as directed. Your blood work will help your physician decide how long to cure you. Atorvastatin is a part of an entire treatment program which may incorporate weight control, exercise, and diet. Follow your physician’s instructions carefully. Store at room temperature away from heat, moisture, and lighting.
Side Effects
- Muscle problems. Atorvastatin can cause serious muscle problems that can lead to kidney problems, including kidney failure. You have a higher chance for muscle problems if you are taking certain other medicines with atorvastatin.
- you feel more tired than usual
- your skin and whites of your eyes get yellow.
- hives
- muscle problems like weakness, tenderness, or pain that happen without a good reason, especially if you also have a fever or feel more tired than usual.
- passing brown or dark-colored urine.
- neck pain
- joint swelling
- yellowing of your skin or the whites of your eyes
- dark amber colored urine
- nausea and vomiting.
- allergic skin reactions.
- allergic reactions including swelling of the face, lips, tongue, and/or throat that may cause difficulty in breathing or swallowing which may require treatment right away.
- Liver problems. Your doctor should do blood tests to check your liver before you start taking atorvastatin and if you have symptoms of liver problems while you take atorvastatin. Call your doctor right away if you have the following symptoms of liver problems:
- feel tired or weak
- general feeling of discomfort (malaise)
- upper belly pain
- loss of appetite
- fever
- stomach pain.
Interactions
Decreased elimination of Lipitor increase the risk of muscle toxicity and could increase levels of Lipitor. Lipitor shouldn’t be combined. Examples of drugs comprises: erythromycin, ketoconazole, itraconazole, clarithromycin, telithromycin, cyclosporine, nefazodone, and HIV protease inhibitors like indinavir and ritonavir. Large quantities of grape fruit juice will increase blood levels of Lipitor and shouldn’t be taken.
The risk of muscle fatigue also may increase when combined with Lipitor. Cyclosporine niacin gemfibrozil fenofibrate Lipitor increases the effect of warfarin and the concentration in blood of digoxin. Patients taking Lipitor and warfarin or digoxin ought to be monitored. Cholestyramine decreases the absorption of Lipitor. Lipitor must be granted at least two hours before and at least four weeks. Rifampin raises breakdown of Lipitor. To reduce the probability of the interaction both drugs should be given at the same moment.
Lipitor should not be given after rifampin.
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