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Capecitabine is an cancer medicine that interferes with the growth of cancer cells and slows their distribute.Capecitabine is used to treat colon cancer, obesity, and colorectal or breast cancer which has spread to other parts of the body.Capecitabine is utilised in combination with other cancer medications and/or radiation treatment.Capecitabine might also be used for purposes not listed in this medication guide.
Capecitabine is a prodrug that’s selectively tumour-activated to the cytotoxic moiety, fluorouracil, by thymidine phosphorylase, an enzyme found in greater concentrations in many tumors when compared with normal cells or plasma. Fluorouracil is further metabolized to two active metabolites, 5-fluoro-2′-deoxyuridine 5′-monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP), in normal and tumour cells. These metabolites cause cell injury by two different mechanisms. First, FdUMP and the folate cofactor, N5-10-methylenetetrahydrofolate, bind to thymidylate synthase (TS) to form a covalently bound ternary complex. This binding inhibits the creation of thymidylate from 2′-deaxyuridylate. Thymidylate is the necessary precursor of thymidine triphosphate, which is essential for the synthesis of DNA, therefore a deficiency of this compound can inhibit cell division. Second, nuclear transcriptional enzymes can wrongly incorporate FUTP in place of uridine triphosphate (UTP) during the synthesis of RNA. This metabolic error can interfere with RNA processing and protein synthesis via the creation of fraudulent RNA.
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How to use capecitabine
Capecitabine is taken twice per day. Follow the directions. Don’t take this medication in bigger or smaller quantities or for longer than suggested. Capecitabine is provided in a 3-week treatment cycle, and you may need to take the medication. Your doctor will determine how long to treat you. Capecitabine is just part of a therapy plan which may also consist of medications.
Follow the dosing directions of your doctor . Capecitabine needs to be taken with food or within 30 minutes. Require capecitabine Of water. Call your health care provider if you’re sick with nausea or vomiting, if you’re not able to eat due to stomach disease, or whether you are sweating more than normal.
Illness can cause dehydration or kidney failure. You might need medical evaluations to be certain this medication is not causing harmful effects. Your cancer therapies may be delayed based on the outcomes of the tests. Capecitabine can have lasting effects on your body. When you stop using this medicine you might need regular tests. You must stay under the care of a doctor while you’re taking capecitabine.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not being used. Read medication guides all information, and documentation provided to you. Ask your doctor or pharmacist if you’ve some questions.
- Vomiting – Tell your doctor if you vomit more than once in a 24-hour time period
- Fever or Infection – Tell your doctor if you have a temperature of 100.5В°F or greater, or other signs of infection Your doctor may tell you to lower the dose or to stop capecitabine treatment for a while. If caught early, most of these side effects usually improve after you stop taking capecitabine. If they do not improve within 2 to 3 days, call your doctor again. After your side effects have improved, your doctor will tell you whether to start taking capecitabine again and what dose to take. Adjusting the dose of capecitabine to be right for each patient is an important part of treatment.
- Diarrhea – Tell your doctor if you have an additional 4 bowel movements each day beyond what is normal or any diarrhea at night
- diarrhea, nausea, vomiting, sores in the mouth and throat (stomatitis), stomach area pain (abdominal pain), upset stomach, constipation, loss of appetite, and too much water loss from the body (dehydration). These side effects are more common in patients age 80 and older.
- Nausea – Tell your doctor if you lose your appetite, and the amount of food you eat each day is much less than usual
- tiredness, weakness, dizziness, headache, fever, pain (including chest, back, joint, and muscle pain), trouble sleeping, and taste problems These side effects may differ when taking capecitabine with docetaxel (Taxotere). Please consult your doctor for possible side effects that may be caused by taking capecitabine with docetaxel (Taxotere).
- hand-and-foot syndrome (palms of the hands or soles of the feet tingle, become numb, painful, swollen or red), rash, dry, itchy or discolored skin, nail problems, and hair loss
- Stomatitis: Tell your doctor if you have pain, redness, swelling or sores in your mouth
- Hand-and-Foot Syndrome – Tell your doctor if you have pain, swelling or redness of your hands or feet that prevents normal activity