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Clarithromycin Information
Clarithromycin is a macrolide antibiotic. Clarithromycin fights bacteria in your body.Clarithromycin is used to treat many distinct kinds of bacterial infections affecting the skin and respiratory tract. Clarithromycin is used along with other medications to treat stomach ulcers.Clarithromycin may also be used for purposes not listed in this medication guide.
Clarithromycin is first metabolized to 14-OH clarithromycin, which is active and works synergistically with its parent compound. As with other macrolides, it then penetrates bacteria cell wall and reversibly binds to domain V of the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome, blocking translocation of aminoacyl transfer-RNA and polypeptide synthesis. Clarithromycin also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump.
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How to use clarithromycin
Follow all directions on your prescription label. Do not take this medicine in smaller or bigger amounts or for longer than suggested. You might take clarithromycin tablets and oral suspension with or without food. Clarithromycin pills should be taken with meals. Do not crush, chew, or break an extended-release tablet.
Shake the suspension well just until a dose is measured by you. Measure medicine with the dosing syringe supplied, or with a distinctive dose-measuring spoon or medicine cup. If you don’t have a dose-measuring device, ask your pharmacist for one. Use this medication. Clarithromycin is given for as many as 7. Doses can also increase. Clarithromycin won’t treat a viral illness like a common cold or the flu.
Store at room temperature away from heat and moisture. Keep the bottle tightly closed when not being used. Don’t keep the liquid in a refrigerator. Throw away any liquid that has not been used within 14 days.
Side Effects
- rash
- nausea
- abnormal taste
- stomach pain
- diarrhea
- headache
- indigestion
- diarrhea
- stomach pain or discomfort
- vomiting
- headache (2%)
Interactions
Clarithromycin interacts with several drugs because it lowers the activity of liver enzymes which breakdown medications. This contributes to increased blood levels and side effects in the affected medication. Examples of these interactions comprise olchicine (Colcrys), simvastatin, lovastatin, atorvastatin, verapamil, amlodipine, and diltiazem. Clarithromycin increases blood levels of vardenafil, tadalafil, sildenafil, theophylline and carbamazepine , thus side effects of these drugs.
Ritonavir and atazanavir raise blood levels of while efavirenz, nevirapine, rifampin, reduce blood levels of clarithromycin. Blood levels of clarithromycin might boost while both medication or blood flow increase. When clarithromycin is combined the incidence of heart beats may increase.