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Clopidogrel Information
Clopidogrel helps to stop platelets in your blood. Negative blood clots may happen with certain heart or blood vessel conditions.Clopidogrel is used to prevent blood clots and in people with certain ailments of blood vessels or the heart.Clopidogrel may also be utilized for purposes.
The active metabolite of clopidogrel prevents binding of adenosine diphosphate (ADP) to its platelet receptor, impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. It is proposed that the inhibition involves a defect in the mobilization in the storage sites of their platelet granules into the outer membrane. He drug specifically and irreversibly inhibits the P2Y12 subtype of ADP receptor, and this can be significant in aggregation of platelets and cross-linking by the protein fibrin. No immediate interference occurs with the GPIIb/IIIa receptor. Since the glycoprotein GPIIb/IIIa complicated is the major receptor for fibrinogen, its diminished activation prevents fibrinogen binding to platelets and inhibits platelet aggregation. By obstructing the amplification of platelet activation by released ADP, platelet aggregation induced by agonists besides ADP is also inhibited by the active metabolite of clopidogrel.
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How to use clopidogrel
Follow all instructions. Do not take this medicine in smaller or bigger quantities or for longer than recommended. Clopidogrel may be taken with or without meals. It can also make it simpler for you to bleed from a slight injury since clopidogrel keeps your blood from clotting. Speak to your physician or seek emergency medical care if you have. If you require surgery or dental work, tell the dentist or surgeon beforehand that you are using clopidogrel.
You might have to quit using the medication for a brief time to stop bleeding. Follow your doctor’s directions and get started taking clopidogrel again. You shouldn’t stop using this medication. Use clopidogrel even if you have no signs or feel fine. Store at room temperature away from heat and moisture.
Side Effects
- your skin or the whites of your eyes are yellow (jaundice)
- your skin looks very pale
- confusion
- fast heart rate or feeling short of breath
- fever
- stroke
- coma
- you feel tired or weak
- nausea, vomiting, or diarrhea
- headache
- See “Drug Precautions” section
- A blood clotting problem called Thrombotic Thrombocytopenic Purpura (TTP). TTP can happen with clopidogrel, sometimes after a short time (less than 2 weeks). TTP is a blood clotting problem where blood clots form in blood vessels; and can happen anywhere in the body. TTP needs to be treated in a hospital right away, because it may cause death. Get medical help right away if you have any of these symptoms and they can not be explained by another medical condition:
- purplish spots (called purpura) on the skin or in the mouth (mucous membranes) due to bleeding under the skin
- speech changes
- stomach area (abdominal) pain
- low amount of urine, or urine that is pink or has blood in it
- vision changes
- seizure
Interactions
The combination of clopidogrel with anti inflammatory anti-inflammatory drugs like ibuprofen, naproxen, diclofenac, etodolac, nabumetone , fenoprofen, flurbiprofen, indomethacin, ketoprofen, oxaprozin, piroxicam, sulindac , tolmetin, and mefenamic acid may increase the chance of stomach and intestinal bleeding. Mixing clopidogrel with warfarin or other drugs the risk of bleeding increases.
Clopidogrel is converted into its active form by enzymes in the liver. Medicines that decrease the action of these enzymes, for esomeprazole, omeprazole or example can lessen the action of clopidogrel and should not be used with clopidogrel. Other drugs that also may respond with clopidogrel in an identical manner include fluoxetine, cimetidine, fluconazole, ketoconazole, voriconazole, ethaverine, felbamate, and fluvoxamine.