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Clotrimazole is an antifungal medicine. It is like an antibiotic but is used to treat yeast infections. Cosmetic clotrimazole is used to treat and protect against yeast infections of the throat and mouth.Clotrimazole may also be used for purposes apart from those listed in this medication guide.
Clotrimazole interacts with yeast 14-О± demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of this membrane. In this manner, clotrimazole inhibits ergosterol synthesis, leading to increased cellular permeability. Clotrimazole can also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the conversion of yeasts into mycelial forms as well as the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of potassium and calcium ions throughout the cell membrane by blocking the ion transfer pathway known as the Gardos channel.
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How to use clotrimazole
Take clotrimazole. The troches should be permitted to dissolve in your mouth. Suck on one troche at a time till it is completely dissolved, usually thirty minutes. Do not chew or swallow the troches whole. The troches are often utilized five times each day. Follow your physician’s directions. Store clotrimazole in room temperature away from heat and moisture.
- Itching in the mouth
- Unpleasant mouth sensations