Clozapine Hydrochloride

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Brand Names
Clozaril, Fazaclo, Versacloz

Clozapine hydrochloride Information

Clozapine is an antipsychotic medicine works by changing the actions of chemicals in your mind.Clozapine is used in the treatment of acute schizophrenia, or to decrease the danger of suicidal behavior in people with schizophrenia or similar disorders.Clozapine is available only from a pharmacy under a program.Clozapine may be utilized for purposes.

Used for treatment: Suicidal Behaviour, Treatment-resistant Schizophrenia, Advanced dopaminomimetic psychosis

Clozapine’s antipsychotic action is likely mediated through a combination of antogistic effects at D2 receptors in the mesolimbic pathway and 5-HT2A receptors in the adrenal gland. D2 antagonism alleviates positive symptoms while 5-HT2A antagonism alleviates negative symptoms.

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How to use clozapine hydrochloride

Follow all directions. Your physician may sometimes change your dosage. Do not use this medication in smaller or bigger quantities or for longer than suggested. Clozapine can be taken with or without meals. The orally-disintegrating pill May be obtained without water. Maintain the pill in its blister pack until you’re prepared to take it. Open the package and then peel back the foil. Do not push a tablet or you may damage the pill. Use hands to eliminate the tablet and place it in your mouth.

Don’t swallow the tablet whole. Let it dissolve in your mouth. If wanted, you may drink liquid to help absorb the pill that is dissolved. If your physician has prescribed one-half of an orally-disintegrating tablet, you will need to split the tablet in half. Throw the other half away. Do not save it for later use. Clozapine can reduce blood cells that help your body fight infections, especially in women and older adults, also in or have problems that are serious.

This will make it more easy for you to create a life-threatening or serious illness. Your blood will have to get tested. Your treatments may be delayed based on the outcomes of these tests. Tell the physician beforehand which you are using clozapine, if you require surgery. You may need to quit using the medicine for a short while. You should not quit using clozapine suddenly or you could have unpleasant withdrawal symptoms. Follow the instructions of your doctor about tapering your own dosage.

Clozapine may have lasting effects on your body. After you stop using this medicine, you might require regular tests. Store at room temperature away from heat and moisture.

Side Effects

  • low blood pressure
  • sedation
  • tremor
  • syncope (fainting or “passing out”)
  • dry mouth
  • visual disturbances
  • nausea
  • dizziness/vertigo
  • tachycardia (fast heartbeat)
  • fever
  • headache
  • hypersalivation
  • constipation
  • sweating


Risperidone may cause an increase in the amount of clozapine. This could lead to an increased chance of unwanted effects from clozapine.