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Cyclophosphamide Information
Cyclophosphamide is an cancer medication that interferes with the growth and spread of cancer cells within the body.Cyclophosphamide can be used to treat various types of cancer. Cyclophosphamide is also used to treat cases of nephrotic syndrome In kids. Cyclophosphamide may also be used for purposes not listed in this medication guide.
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, leading to the DNA being fragmented by repair enzymes in their own attempts to substitute the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage through the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides resulting in mutations.
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How to use cyclophosphamide
Stick to all instructions. Do not take this medication in larger or smaller quantities or for more than proposed.
Side Effects
- vomiting
- weight loss
- loss of appetite
- nausea
- temporary or permanent sterility
- diarrhea
- stomach pain
- temporary hair loss
- changes in skin or nail color
- mouth sores
- menstrual changes
Interactions
Allopurinol enhances cyclophosphamide’s ability to decrease generation of blood cells. Cyclophosphamide raises the action of blood thinners like warfarin raises the occurrence of heart failure that’s caused by doxorubicin, and reduces the efficacy of antibiotics ciprofloxacin. Quick GuidePancreatic Cancer Symptoms, Causes, and Treatment