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Danocrine
Danazol Information
Danazol is a type of a steroid. Danazol prevents the discharge of hormones also impacts the gland.Danazol is used to treat endometriosis and fibrocystic breast disorder. Danazol is also used to stop attacks of angioedema .Danazol may also be used for purposes not listed in this medication guide.
As a gonadotropin inhibitor, danazol inhibits the pituitary-ovarian axis maybe by inhibiting the output of pituitary gonadotropins. Danazol also depresses the preovulatory surge in output signal of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), thereby reducing ovarian estrogen production. Danazol can also directly inhibits ovarian steroidogenesis; bind to androgen, progesterone, and glucocorticoid receptors; link to sex-hormone-binding globulin and corticosteroid-binding globulin; and increases the metabolic clearance rate of progesterone. Another mechanism of action by which danazol may utilize to facilitate regression of endometriosis is by decreasing IgG, IgM, and IgA concentrations, in addition to phospholipid and IgG isotope autoantibodies. In the treatment of endometriosis, as a consequence of suppression of ovarian function, danazol causes both the normal and ectopic endometrial cells to become inactive and atrophic. This leads to anovulation and related amenorrhea. In fibrocystic breast disorder, the exact mechanism of action of danazol is unknown, but may be related to suppressed estrogenic stimulation as a consequence of decreased ovarian production of estrogen. A direct impact on prostate gland sites in breast tissue is also possible. This also leads to a disappearance of nodularity, relief of pain and tenderness, and possibly changes in the menstrual pattern. In terms of hereditary angioedema, danazol corrects the underlying biochemical deficiency by increasing serum levels of this deficient C1 esterase inhibitor, leading to increased serum levels of the C4 part of the complement system. (Source: PharmGKB)
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How to use danazol
Take exactly as prescribed by your doctor. Don’t take in larger or smaller amounts or for longer than suggested. Follow the instructions on your prescription label. Women who take danazol to deal with breast disease should begin the medication. Danazol is usually given for 6 to 9 months to deal with fibrocystic breast disease or endometriosis. You may want to use the medication long-term, to prevent attacks of hereditary angioedema. Follow the instructions of your doctor.
Your doctor may change your dose. Your medication needs can change if you get sick, if you have even a medical emergency or surgery, or have an illness or illness. Inform your physician. Don’t alter your medication dosage or program without your doctor’s advice. Utilize danazol to get the most benefit. Try not to miss any doses.
Take your prescription refilled before you run out of medicine entirely. Blood tests may be needed by you in your doctor’s office when using danazol. Visit your doctor regularly. It can take several weeks before your symptoms improve. Continue using the medication and tell your physician if your symptoms do not improve or if they become worse during treatment. This medicine can cause results.
Side Effects
- acne
- skin rash
- nervousness
- hair growth in unusual amounts and places
- water retention
- sweating
- weight gain
- menstrual cycle changes
- liver problems
- flushing
- hoarseness or sore throat
- vaginal dryness and irritation
- decrease in breast size