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Brand Names
Cardoxin, Digitek, Digox, Lanoxicaps, Lanoxin

Digoxin Information

Digoxin is derived from a digitalis plant’s leaveslife. Digoxin helps make your heart beat stronger and using a more regular rhythm.Digoxin is used in the treatment of heart failure.Digoxin can be used to treat atrial fibrillation .Digoxin may also be utilized for purposes not listed in this medication guide.

Used for treatment: Chronic Atrial Fibrillation, NYHA Class I or II heart failure, NYHA Class III Heart Failure

Digoxin inhibits the Na-K-ATPase membrane pump, leading to an increase in intracellular sodium. The sodium calcium exchanger (NCX)in turn tries to extrude the sodium and in so doing, pumps in more calcium. Increased intracellular levels of calcium can promote activation of contractile proteins (e.g., actin, myosin). Digoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and diminishing the maximal diastolic potential.

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How to use digoxin

Follow all instructions on your prescription label. Don’t take this medication in bigger or smaller amounts or for longer than recommended. Try to take the medication. Measure medication with all the dosing syringe supplied, or using a unique dose-measuring spoon or medicine cup. If you do not own a dose-measuring device, ask your pharmacist. You may need blood tests when utilizing digoxin. Your kidney function may have to get assessed.

Use digoxin frequently even in case you feel good or have no signs. You should not stop using digoxin suddenly. Stopping abruptly may cause your condition worse.

Side Effects

  • Rash
  • Diarrhea
  • Feet or hands swelling
  • Weakness
  • Upset stomach
  • Nausea
  • Loss of appetite
  • Vomiting
  • Mental changes (anxiety, depression, hallucination)
  • Dizziness
  • Vision changes (blurred or yellow)


Drugs like gentamicin, tetracycline, ranolazine, verapamil, quinidine, amiodarone , indomethacin, alprazolam, spironolactone , and itraconazole can increase the chance of toxicity and digoxin levels. The co-administration of digoxin and beta-blockers or calcium channel blockers or CCBs, which reduce heart rate, can cause heart rate slowing.

Reduction in blood glucose or magnesium levels may predispose individuals. Ritonavir and Saquinavir increase the quantity of digoxin from the human body and might lead to digoxin toxicity. Mirabegron increases blood levels. The dose of digoxin ought to be utilized if by people that are also currently using mirabegron. Acidity may increase blood levels of digoxin.