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Diltiazem hydrochloride Information
Diltiazem is a calcium channel blocker. This works by relaxing the muscles of the heart and blood vessels.Diltiazem is used to treat certain heart rhythm disorders, angina, and hypertension.Diltiazem may also be used for purposes not listed in this medication guide.
Possibly by deforming the station, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium in the sarcoplasmic reticulum, diltiazem, such as verapamil, inhibits the influx of extracellular calcium across the bronchial and vascular smooth muscle cell membranes. The consequent inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.
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How to use diltiazem hydrochloride
Follow all instructions. Your dose may change. Do not use this medication in bigger or smaller amounts or for longer than advised. Do not crush, chew, break, or open capsule or an extended-release tablet. Ask your doctor, to make swallowing easier or pharmacist if a diltiazem cans open capsule and sprinkle the medicine. Swallow away without chewing. Do not save the mixture for later use. Use diltiazem regularly to get the most benefit.
You shouldn’t quit using diltiazem suddenly. Stopping suddenly may cause your illness worse. Continue using this medication even if you are feeling good, if you’re being treated for hypertension. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Your blood pressure will have to be checked often. You may require blood tests. Store at room temperature away from heat and moisture.
Side Effects
- Flushing
- Itching and burning at the site of injection
- Constipation
- Slow heartbeat
- Dizziness or lightheadedness
- Diarrhea
- Headache
- Flushing
- Edema
- Nasal congestion
- Cough
- Rash
- Weakness
- Low blood pressure
- Vomiting
Interactions
Administration of diltiazem with digoxin can increase blood levels. Consequently, blood levels of digoxin usually are monitored to avoid toxicity from digoxin. Similarly administration of diltiazem with an anti inflammatory medication, carbamazepine , can boost blood levels of the seizure medication, and occasionally lead to toxicity. Diltiazem increases blood levels of atorvastatin, lovastatin and simvastatin, potentially increasing the chance of negative effects.
Diltiazem may boost blood levels of buspirone, midazolam, triazolam and diazepam by decreasing their breakdown and removal by the liver from the body. This can lead to toxicity from these drugs. Rifampin reduces the effect of diltiazem by decreasing its levels from blood to undetectable levels.