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Diltiazem Information
Diltiazem is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels.Diltiazem is used to treat angina hypertension, and heart rhythm disorders.Diltiazem may also be used for purposes not listed in this medication guide.
Perhaps by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, diltiazem, like verapamil, inhibits the influx of extracellular calcium across the bronchial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the adrenal gland.
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How to use diltiazem
Follow all instructions. Your dose may sometimes change. Do not use this medication in larger or smaller amounts or for longer than advised. Don’t crush, chew, break, or start capsule or an extended-release tablet. Swallow it whole. To make swallowing easier, ask your physician or pharmacist if a diltiazem cans open capsule and sprinkle the medicine. Swallow right away without chewing. Do not save the mixture for later use. Utilize diltiazem regularly to get the most benefit.
Get your prescription refilled before you run out of medicine. You shouldn’t stop using diltiazem. Stopping abruptly may cause your condition worse. Continue using this medicine even in case you are feeling well, if you’re being treated for hypertension. High blood pressure has no signs. You might want to use blood pressure medication for the remainder of your life.
Your blood pressure will need to get checked often. You may require regular blood tests. Store at room temperature away from heat and moisture.
Side Effects
- Flushing
- Itching and burning at the site of injection
- Constipation
- Slow heartbeat
- Dizziness or lightheadedness
- Diarrhea
- Headache
- Flushing
- Edema
- Nasal congestion
- Cough
- Rash
- Weakness
- Low blood pressure
- Vomiting
Interactions
Digoxin blood levels can increase. Therefore, blood levels of digoxin usually are monitored to avoid toxicity from digoxin. Similarly administration of diltiazem carbamazepine, with an anti inflammatory medicine , can boost blood levels of the seizure medication, and occasionally cause toxicity. Diltiazem increases blood levels of lovastatin, atorvastatin and simvastatin, potentially increasing the risk of negative results.
Diltiazem may boost blood levels of buspirone, midazolam , triazolam and diazepam by reducing their breakdown and elimination from the body by the liver. This can result in toxicity from these drugs. Rifampin reduces the effect of diltiazem by reducing its levels to undetectable levels from blood.