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Domperidone acts as a gastrointestinal emptying (postponed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to the peripheral dopamine receptor blocking properties. Domperidone eases gastric emptying and decreases small intestine transit time by raising esophageal and gastric peristalsis and by reducing esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are linked to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and also in the gastric level. It’s strong affinities for the D2 and D3 dopamine receptors, that are located in the chemoreceptor trigger zone, located just outside the blood brain barrier, which – among others – regulates nausea and vomiting
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