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Erythromycin phosphate Information
Erythromycin is a macrolide antibiotic. Erythromycin fights bacteria in your system.Erythromycin can be used to treat or protect against distinct sorts of infections brought on by bacteria.Erythromycin may also be used for purposes not listed in this medication guide.
Erythromycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the “P” or donor site so that binding of tRNA (transfer RNA) into the donor site is blocked. Translocation of peptides in the “A” or acceptor site to the “P” or donor website is prevented, and subsequent protein synthesis is inhibited. Erythromycin is effective only against actively dividing organisms. The exact mechanism by which erythmromycin reduces lesions of acne vulgaris isn’t completely known: however, the effect appears to be due in part to the antibacterial activity of the drug.
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How to use erythromycin phosphate
Follow all instructions on your prescription label. Your physician may change your dose. Do not take this medicine in smaller or larger quantities or for longer than advised. If the child has some alterations in weight, if your child is using this medication, tell your health care provider. Erythromycin doses are based on fat in children. Do not crush, chew, or break tablet or a delayed-release pill. Measure liquid medication with all the syringe supplied, or using a unique dose-measuring spoon or medicine cup.
If you do not have a dose-measuring device, ask your pharmacist. Use this medication for the total length of time. Skipping doses can increase. Erythromycin will not deal with a viral infection such as the frequent cold or influenza. This medicine can cause unusual results . Store at room temperature away from light, heat, and moisture. You might need to store liquid medicine. Follow the storage directions. Liquid medication expires after a short period of time.
Throw away any unused liquid as directed.
Side Effects
- Diarrhea
- Stomach pain
- Vomiting
- Common side effects of oral erythromycin include the following:
- Upset stomach
- Skin rash
- Irritation at the site of application, including dryness, redness, itching, and burning
- Stomach cramps
- Mild skin rash
- Irritation at the injection site
Interactions
Erythromycin when used with drugs such as, amiodarone , bretylium, disopyramide , dofetilide, procainamide , quinidine and sotalol exaggerates the effect of the drugs which may give rise to abnormal heart rhythms such as torsades de pointes. By increasing elimination of erythromycin from the kidneys, which may reduce the efficacy of erythromycin erythromycin blood glucose are reduced by theophyllines like aminophylline, oxtriphylline, and theophylline.
Erythromycin inhibits theophyllines’ metabolism and causes an increase in blood levels of theophylline. High theophylline levels can give rise to side effects like seizures and disturbances in heart rhythm. Therefore, the dose of theophyllines should be lowered or theophylline levels in the blood ought to be quantified in patients taking erythromycin.
Mixing erythromycin with ergotamine or ydroergotamine has been associated with acute ergot toxicity. This combination should be avoided. Erythromycin prevents digoxin from being removed by the kidneysvessels. Disturbances can be caused by increased amounts of digoxin in heart rhythm. Therefore, it is important to track and fix digoxin doses when coping with erythromycin. Erythromycin prevents warfarin’s elimination from the body which can increase the levels of warfarin in the blood.
Warfarin is an anticoagulant or blood thinner, and an increase in its amount in blood may increase the risk of bleeding. It is crucial to track the effects of warfarin when treating with erythromycin and fix warfarin doses. Erythromycin inhibits the breakdown of HMG-CoA reductase inhibitors like simvastatin, lovastatin and atorvastatin by the liver resulting in increased levels of statins from the blood. Elevated levels of statins could result with rhabdomyolysis that cause death or even may damage the kidneys.
Erythromycin can elevate blood levels of some drugs like carbamazepine by preventing the breakdown of this anti-seizure drug. Therefore, doses of these anti-seizure drugs might have to be reduced during treatment with erythromycin. Blood levels of sildenafil also increase. When treating with erythromycin, the dose of sildenafil should be diminished. Grapefruit juice can prevent the breakdown of erythromycin, resulting in elevated levels of erythromycin from the blood.
For that reason, it is crucial to prevent eating grapefruit or drinking grapefruit juice.