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Erythromycin stearate Information
Erythromycin is a macrolide antibiotic. Erythromycin fights bacteria in your system.Erythromycin is used to treat or protect against diverse types of infections caused by bacteria.Erythromycin may also be used for purposes not listed in this medication guide.
Erythromycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the “P” or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the “A” or acceptor site to the “P” or donor site is prevented, and subsequent protein synthesis is inhibited. Erythromycin is effective only against actively dividing organisms. The exact mechanism by which erythmromycin reduces lesions of acne vulgaris is not completely known: however, the effect appears to be due in part to the antibacterial action of the medication.
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How to use erythromycin stearate
Follow all directions on your prescription label. Your physician may change your dose to make sure to receive the best results. Don’t take this medication in smaller or larger quantities or for longer than suggested. If the child has any changes in weight, if your child is using this medication, tell your physician. Erythromycin doses are according to fat in kids. Do not crush, chew, or break a capsule or tablet. Measure medicine with the syringe provided, or with a unique dose-measuring spoon or medicine cup.
If you do not own a dose-measuring device, ask your pharmacist. Use this medicine. Your symptoms may improve before the infection is completely cleared. Skipping doses may increase. Erythromycin will not deal with a viral infection such as the frequent cold or influenza. This medication can cause odd results with laboratory tests of the pee. Tell any doctor who treats you that you’re currently using erythromycin.
Store at room temperature away from moisture, heat, and lighting. You may want to store medicine. Follow the storage directions on your medication label. Liquid medication expires after a very period of time. Throw away any leftover liquid as directed.
Side Effects
- Diarrhea
- Stomach pain
- Vomiting
- Common side effects of oral erythromycin include the following:
- Upset stomach
- Skin rash
- Irritation at the site of application, including dryness, redness, itching, and burning
- Stomach cramps
- Mild skin rash
- Irritation at the injection site
Interactions
Erythromycin when used with antiarrhythmic medications such as, amiodarone , bretylium, disopyramide , dofetilide, procainamide , quinidine and sotalol exaggerates the effect of these drugs that might give rise to abnormal heart rhythms such as torsades de pointes. By increasing removal of erythromycin from the kidneys, which might lower the efficacy of 29,, blood levels are reduced by theophyllines such as aminophylline, oxtriphylline, and theophylline.
Conversely, erythromycin inhibits the metabolism of theophyllines and also causes an increase in blood levels of theophylline. Theophylline levels that are high can give rise to unwanted effects like seizures and disturbances in heart rhythm. Hence, theophyllines’ dose should be reduced or levels in the blood ought to be quantified in patients taking erythromycin. Mixing erythromycin with ydroergotamine or ergotamine has been associated with acute ergot toxicity.
This combination ought to be avoided. From being removed by the kidneys, erythromycin prevents digoxin; this in turn causes elevated amounts of digoxin in the blood. Disturbances can be caused by increased levels of digoxin in heart rhythm. Therefore, it is very important to monitor and adjust digoxin doses when treating with erythromycin.
Erythromycin prevents the removal of warfarin in the body that may increase the levels of warfarin. Warfarin is a blood thinner, and an increase in its level in blood may increase the chance of bleeding. It’s important to track the effects of warfarin when treating with erythromycin and fix warfarin doses. Erythromycin inhibits HMG-CoA reductase inhibitors such as lovastatin, atorvastatin and simvastatin’s breakdown from the liver leading to elevated amounts of statins in the blood.
Elevated levels of statins could result with rhabdomyolysis that may damage the kidneys or even cause death. By preventing the breakdown of the drug by the liver Erythromycin also can raise blood levels of several anti-seizure drugs like carbamazepine. Therefore, doses of these anti-seizure drugs may need to be reduced during therapy with erythromycin. Blood levels of sildenafil also increase.
When treating with erythromycin the dose of sildenafil should be reduced. Grapefruit juice may prevent the breakdown of erythromycin, resulting from the blood in elevated levels of erythromycin. It is important to avoid eating grapefruit or drinking grapefruit juice during treatment with erythromycin.