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Erythromycin Information
Erythromycin is a macrolide antibiotic. Erythromycin fights bacteria in the body.Erythromycin is used to treat or prevent diverse forms of infections brought on by bacteria.Erythromycin may also be used for purposes.
Erythromycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the “P” or donor website so that binding of tRNA (transfer RNA) into the donor site is blocked. Translocation of peptides from the “A” or acceptor site to the “P” or donor website is prevented, and subsequent protein synthesis is inhibited. Erythromycin is effective only against actively dividing organisms. The precise mechanism whereby erythmromycin reduces lesions of acne vulgaris isn’t completely known: however, the effect appears to be due in part to the antibacterial action of the medication.
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How to use erythromycin
Follow all directions on your prescription label. Your physician may occasionally change your dose. Don’t take this medication in smaller or bigger amounts or for longer than advised. If the child has any alterations in weight, if a child is using this medication, tell your doctor. Erythromycin doses are according to weight in kids. Do not crush, chew, or break a delayed-release capsule or pillcomputer. Measure liquid medicine with all the syringe supplied, or with a distinctive dose-measuring spoon or medicine cup.
If you don’t have a dose-measuring device, ask your pharmacist. Use this medicine. Skipping doses can raise. Erythromycin won’t deal with a viral infection such as influenza or the common cold. Odd results can be caused by this medicine . Tell any doctor who treats you that you’re using erythromycin.
Store at room temperature away from light, heat, and moisture. You may need to store medication. Follow the storage directions. Liquid medicine expires after a period of time. Throw out any unused liquid as directed.
Side Effects
- Diarrhea
- Stomach pain
- Vomiting
- Common side effects of oral erythromycin include the following:
- Upset stomach
- Skin rash
- Irritation at the site of application, including dryness, redness, itching, and burning
- Stomach cramps
- Mild skin rash
- Irritation at the injection site
Interactions
Erythromycin when combined with medications such as, amiodarone , bretylium, disopyramide , dofetilide, procainamide , quinidine and sotalol exaggerates the impact rise to abnormal heart rhythms such as torsades de pointes. By increasing removal of erythromycin by the kidneys, which might reduce the effectiveness of erythromycin blood levels are reduced by theophyllines like aminophylline, oxtriphylline, and theophylline.
Conversely, erythromycin inhibits the metabolism of theophyllines from the liver and also causes an increase. Theophylline levels that are high can give rise to unwanted effects such as seizures and disturbances in heart rhythm. Hence, theophyllines’ dose ought to be reduced or levels in the blood ought to be quantified in patients taking erythromycin.
Combining erythromycin with ergotamine or ydroergotamine was associated with acute ergot toxicity. This combination ought to be avoided. From being removed by the kidneys, digoxin is prevented by erythromycinvessels. Disturbances can be caused by increased levels of digoxin in heart rhythm. For that reason, it is important to monitor and fix digoxin doses when coping with erythromycin.
Erythromycin prevents the elimination of warfarin from the body which can increase the levels of warfarin from the blood. Warfarin is an anticoagulant or blood thinner, and also an increase in its level in blood can increase the risk of bleeding. It is important to track the effects of warfarin and fix warfarin doses when treating with erythromycin. Erythromycin inhibits the breakdown of HMG-CoA reductase inhibitors like lovastatin atorvastatin and simvastatin by the liver. High levels of statins could result with rhabdomyolysis that lead to death or even may damage the kidneys.
By preventing the breakdown of the medication by the 24, Erythromycin also can elevate blood levels of several drugs like carbamazepine. Therefore, doses of these drugs might need to be reduced during therapy. Erythromycin also increases blood levels of sildenafil. When treating with erythromycin, the dose of sildenafil ought to be diminished. Grapefruit juice may prevent the breakdown of erythromycin, resulting in elevated levels of erythromycin in the blood.
It is important to prevent eating grapefruit or drinking grapefruit juice during treatment with erythromycin.