Estradiol Benzoate

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Brand Names
Alora, Climara, Climara Pro, Climaval, Clinagen LA 40, Combipatch, Delatestadiol, Delestrogen, Dep Androgyn, Dep Gynogen, Depo-Estradiol, Depo-Testadiol, Depotestogen, Dioval 40, Dioval XX, Divigel, Duo-Cyp, Dura-Dumone, Dura-Estrin, Duragen, Duratestrin, Elestrin, Elleste Solo, Esclim, Estra-C, Estra-Testrin, Estra-V 40, Estrace, Estraderm, Estragyn LA 5, Estrasorb, Estring, Estro-Cyp, Estro-Span 40, Estrogel, Evamist, Fempatch, Femring, Femtrace, Gynodiol, Gynogen LA 20, Innofem, Lunelle, Medidiol 10, Menaval-20, Menostar, Minivelle, Oestrogel, Prefest, Progynova, Sandrena, Vagifem, Valergen, Vivelle-Dot, Zumenon

Estradiol benzoate Information

Estradiol Is a female sex hormone necessary for many processes in the body. Vaginal goods release estrogen that is absorbed directly through the skin of the vaginal walls. Estradiol topical is used to treat certain symptoms of menopause like tingling, tingling, and itching of irritation or the vaginal area and urgency with bleeding.Estradiol may also be used for purposes aside from those listed in this medication guide.

Used for treatment: Atrophic Vaginitis, Estrogen Deficiency, Metastatic Breast Cancer, Vasomotor Symptoms, Vulvovaginal Atrophy, Advanced androgen dependent Prostate cancer

Estradiol enters target cells freely (e.g., feminine organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to make specific proteins which express the effect of estradiol on the goal cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins also suppress follicle-stimulating hormone (FSH) from the anterior pituitary.

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How to use estradiol benzoate

Adhere to all instructions on your prescription label. Do not take this medicine in larger or bigger amounts or for more than recommended.

Side Effects

  • redness or irritation of the skin that was covered by the estradiol patch, cream, or gel
  • anxiety
  • changes in mood
  • constipation
  • heartburn
  • nausea
  • hair loss
  • unwanted hair growth
  • painful menstrual periods
  • runny nose or congestion
  • cough
  • difficulty wearing contact lenses
  • headache
  • vomiting
  • breast pain or tenderness
  • swelling, redness, burning, irritation or itching of the vagina
  • gas
  • vaginal discharge
  • depression
  • darkening of skin on face (may not go away even after you stop using transdermal estradiol)
  • back, neck, or muscle pain
  • change in sexual desire
  • weight gain or loss


Estrogens can inhibit the metabolism of cyclosporine, resulting in increased cyclosporine blood levels. Improved blood levels can lead to kidney and/or liver damage. Cyclosporine concentrations can be monitored if this combination can not be avoided, and the dose of cyclosporine may be corrected to ensure its blood levels aren’t elevated. Estrogens seem to raise the chance of liver disease in patients receiving dantrolene via an unknown mechanism. Women over 35 decades of age and people with a history of kidney disease are particularly at risk.

Estrogens increase the liver’s capacity to manufacture variables. Because of this, patients receiving warfarin have to be monitored for loss of anticoagulant effect if an estrogen is inserted when warfarin is already being taken. Rifampin, barbiturates, carbamazepine, griseofulvin, phenytoin, primidone and St. John’s wort trainings can increase the elimination of estrogen by improving the liver’s ability to enhance it.

Use may result in reduction of these beneficial effects of estrogens. On the flip side, drugs may increase the side effects of estrogen and such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice can reduce the liver’s capacity. Estrogens may increase effects and the amounts of drugs, ropinirole, tipranavir and exogenous corticosteroids that include theophylline. Estrogens may reduce the effects of anastrozole, aripiprazole, axitinib, hyaluronidase, saxagliptin, somatropin, ibrutinib, and ursodiol and the degrees.

Estrogen levels and effects could be decreased by dabrafenib, deferasirox, peginterferon Alfa-2b, P-glycoprotein inducers, tocilizumab and herbs . Herbaceous plants with contents like estrogens may increase the side effects of estrogens. Effects and estrogen levels may be increased from P-glycoprotein inhibitors, nonsteroidal anti inflammatory drugs known as COX-2 inhibitors such as celecoxib and ascorbic acid.