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Estradiol hemihydrate Information
Estradiol Is a female sex hormone necessary for many processes in the human body. Vaginal goods release estrogen that is absorbed directly through the skin of the wall. Estradiol topical is used to treat signs of menopause like tingling, tingling, and itching in urgency and the area or irritation .Estradiol may also be used for purposes apart from those listed in this medication guide.
Estradiol moves target cells freely (e.g., feminine organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and modulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to make certain proteins that express the effect of estradiol on the goal cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and inhibit follicle-stimulating hormone (FSH) from the anterior pituitary.
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How to use estradiol hemihydrate
Follow all directions in your prescription label. Do not take this medication at smaller or bigger amounts or for more than advocated.
Side Effects
- redness or irritation of the skin that was covered by the estradiol patch, cream, or gel
- anxiety
- changes in mood
- constipation
- heartburn
- nausea
- hair loss
- unwanted hair growth
- painful menstrual periods
- runny nose or congestion
- cough
- difficulty wearing contact lenses
- headache
- vomiting
- breast pain or tenderness
- swelling, redness, burning, irritation or itching of the vagina
- gas
- vaginal discharge
- depression
- darkening of skin on face (may not go away even after you stop using transdermal estradiol)
- back, neck, or muscle pain
- change in sexual desire
- weight gain or loss
Interactions
Estrogens can inhibit the metabolism of cyclosporine, resulting in cyclosporine blood sugar levels. Improved blood levels can lead to kidney and/or liver damage. If this combination cannot be avoided concentrations can be monitored, and the dose of cyclosporine may be adjusted to assure that its blood levels aren’t elevated.
Estrogens seem to increase the risk of liver disease in patients receiving dantrolene through an unknown mechanism. Women over 35 years of age and people with a history of kidney disease are particularly at risk. Estrogens increase the liver’s ability to manufacture clotting factors. Due to this, patients receiving warfarin need to be monitored for loss of anticoagulant effect when warfarin is already being taken, if an estrogen is added. Rifampin, barbiturates, carbamazepine, griseofulvin, phenytoin, primidone and St.
John’s wort preparations can all increase the removal of estrogen by enhancing the liver’s capacity to metabolize it. Concurrent use may bring about decrease of these effects of estrogens. On the flip side, drugs like erythromycin, clarithromycin, ketoconazole, itraconazole , ritonavir and grapefruit juice may reduce the liver’s ability and may increase the unwanted effects of estrogen.
Estrogens may increase the amounts and effects of ropinirole exogenous corticosteroids, tipranavir and medications that include theophylline. Estrogens may reduce the levels and the consequences of anastrozole. Estrogen levels and effects may be diminished by dabrafenib, deferasirox, peginterferon Alfa-2b, P-glycoprotein inducers, tocilizumab and herbs . The side effects of estrogens may increase. Estrogen effects and levels may be raised by dehydroepiandrosterone inhibitors, nonsteroidal anti inflammatory drugs known as COX-2 inhibitors such as celecoxib and ascorbic acid.