Estradiol Valerate

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Brand Names
Alora, Climara, Climara Pro, Climaval, Clinagen LA 40, Combipatch, Delatestadiol, Delestrogen, Dep Androgyn, Dep Gynogen, Depo-Estradiol, Depo-Testadiol, Depotestogen, Dioval 40, Dioval XX, Divigel, Duo-Cyp, Dura-Dumone, Dura-Estrin, Duragen, Duratestrin, Elestrin, Elleste Solo, Esclim, Estra-C, Estra-Testrin, Estra-V 40, Estrace, Estraderm, Estragyn LA 5, Estrasorb, Estring, Estro-Cyp, Estro-Span 40, Estrogel, Evamist, Fempatch, Femring, Femtrace, Gynodiol, Gynogen LA 20, Innofem, Lunelle, Medidiol 10, Menaval-20, Menostar, Minivelle, Oestrogel, Prefest, Progynova, Sandrena, Vagifem, Valergen, Vivelle-Dot, Zumenon

Estradiol valerate Information

Estradiol Is a female sex hormone. Estradiol vaginal products release estrogen that is absorbed directly through the skin of the vaginal walls. Estradiol topical is used to treat signs of menopause such as itching, tingling, and itching in urgency and the area or irritation with urination.Estradiol may also be used for purposes other than those listed in this medication guide.

Used for treatment: Atrophic Vaginitis, Estrogen Deficiency, Metastatic Breast Cancer, Vasomotor Symptoms, Vulvovaginal Atrophy, Advanced androgen dependent Prostate cancer

Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target mobile, and modulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to make specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), along with other serum proteins also inhibit follicle-stimulating hormone (FSH) from the anterior pituitary.

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How to use estradiol valerate

Follow all instructions. Do not take this medicine in bigger or bigger amounts or for longer than proposed.

Side Effects

  • redness or irritation of the skin that was covered by the estradiol patch, cream, or gel
  • anxiety
  • changes in mood
  • constipation
  • heartburn
  • nausea
  • hair loss
  • unwanted hair growth
  • painful menstrual periods
  • runny nose or congestion
  • cough
  • difficulty wearing contact lenses
  • headache
  • vomiting
  • breast pain or tenderness
  • swelling, redness, burning, irritation or itching of the vagina
  • gas
  • vaginal discharge
  • depression
  • darkening of skin on face (may not go away even after you stop using transdermal estradiol)
  • back, neck, or muscle pain
  • change in sexual desire
  • weight gain or loss


Estrogens can inhibit the metabolism of cyclosporine, resulting in increased cyclosporine blood levels. Such blood levels could lead to kidney and/or liver damage. Cyclosporine concentrations can be tracked, if this combination can’t be prevented, and the dosage of cyclosporine can be corrected to ensure its blood levels aren’t elevated. Estrogens appear to increase the chance of liver disease in patients receiving dantrolene. Women over 35 years old and those with a history of kidney disease are especially at risk.

Estrogens increase the liver’s ability to manufacture clotting factors. Due to this, in case a estrogen is added when warfarin is being taken, patients need to be monitored for loss of effect. Rifampin, barbiturates, carbamazepine, griseofulvin, phenytoin, primidone and St. John’s wort trainings can increase the elimination of estrogen by enhancing the liver’s capacity to enhance it.

Use may bring about reduction of the effects of estrogens. On the other hand, drugs like erythromycin, clarithromycin, ketoconazole, itraconazole , ritonavir and grapefruit juice may decrease the liver’s capacity and may increase the side effects of estrogen. Estrogens may increase the amounts and effects of ropinirole exogenous corticosteroids, tipranavir and medications that contain theophylline.

Estrogens may reduce the levels and the consequences of anastrozole. Estrogen levels and effects may be diminished by dabrafenib, deferasirox, peginterferon Alfa-2b, P-glycoprotein inducers, tocilizumab and herbs . Herbs with contents may increase the negative effects of estrogens. Estrogen levels and effects may be raised from dehydroepiandrosterone inhibitors, nonsteroidal anti inflammatory drugs known as COX-2 inhibitors such as acid.