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Brand Names

Ethionamide Information

Ethionamide is an antibiotic that fights with germs.Ethionamide is used in the treatment of tuberculosis . Ethionamide has to be given in conjunction with tuberculosis drugs and it should not be used alone.Ethionamide may also be utilized for purposes.

Used for treatment: Active Tuberculosis

Ethionamide may be bacteriostatic or bactericidal in action, based upon the concentration of the drug achieved at the website of infection and the susceptibility of the infecting organism. Ethionamide, like prothionamide and pyrazinamide, is a nicotinic acid derivative related to isoniazid. It is thought that ethionamide undergoes intracellular modification and behaves in a similar manner to isoniazid. Isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. Specifically isoniazid inhibits InhA, the enoyl reductase from Mycobacterium tuberculosis, by forming a covalent adduct with the NAD cofactor. It’s the INH-NAD adduct that functions as a slow, tight-binding competitive inhibitor of InhA.

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How to use ethionamide

Your doctor will perform blood tests to be certain that you do not have conditions that would prevent you. Follow all directions. Don’t take this medication in smaller or bigger amounts or for longer than recommended. You may take ethionamide with or without meals. Ethionamide might be taken with food if it upsets your stomach. You might need regular blood tests to look at your liver and thyroid function. You might require vision examinations.

Use this medicine. Your symptoms may improve before the infection is completely cleared. Doses may also raise. Ethionamide will not deal with a viral infection such as the flu or a frequent cold. Store at room temperature away from heat and moisture.

Side Effects

  • weight loss
  • increased saliva
  • inflammation of the mouth
  • diarrhea
  • vomiting
  • stomach pain
  • nausea
  • metallic taste

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