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Monopril
Fosinopril sodium Information
Fosinopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme.Fosinopril is used to treat high blood pressure Or heart collapse. Fosinopril may also be utilized for purposes not listed in this medication guide.
There are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; along with the testicular isoform, which has a lower molecular mass and is thought to play a role in sperm maturation and binding of sperm to the oviduct epithelium. Somatic ACE contains two functionally active domains, C and N, which arise in tandem gene duplication. Although both domains have high sequence similarity, they play different physiological functions. The C-domain is predominantly involved in blood pressure regulation while the N-domain plays a role in hematopoietic stem cell differentiation and proliferation. ACE inhibitors bind to and inhibit the activity of both domain names, but have much greater affinity for and inhibitory action against the C-domain. Fosinoprilat, the active metabolite of fosinopril, competes with ATI for binding to ACE and inhibits and enzymatic proteolysis of ATI into ATII. Decreasing ATII levels in the body decreases blood pressure by inhibiting the pressor effects of ATII as clarified from the Pharmacology section above. Fosinoprilat also causes an increase in plasma renin activity probably because of loss of feedback inhibition mediated by ATII on the launch of renin and/or stimulation of adrenal mechanisms via baroreceptors.
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How to use fosinopril sodium
Follow all directions on your prescription label. Your dosage may sometimes change. Do not use this medication in larger or smaller amounts or for longer than recommended. Fosinopril may be obtained with or without meals. Call your health care provider if you’ve got vomiting or nausea, or whether you’re sweating more than usual.
This can result in electrolyte disorders very low blood pressure, or kidney failure. While utilizing fosinopril, blood tests may be needed by you at your doctor’s office. Your blood pressure will need to get checked. If you need medical tests or surgery, tell your doctor beforehand that you are using fosinopril.
You may want to quit using the medication for a brief moment. Keep using this medicine even if you feel good, if you’re being treated for high blood pressure. High blood pressure has no signs. You might want to use blood pressure medicine for the rest of your life.
Side Effects
- sore throat
- nausea
- headhache
- fatigue
- vomiting
- diarrhea
- dizziness
- cough