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Brand Names
Esidrix, HydroDIURIL, Microzide, Oretic

Hydrochlorothiazide Information

Hydrochlorothiazide is a thiazide diuretic That helps prevent your body from consuming too much salt, which can cause fluid retention. Hydrochlorothiazide is used to treat high blood pressure .Hydrochlorothiazide may also be used for purposes not listed in this medication guide.

Used for treatment: Acidosis, Renal Tubular, Calcium Nephrolithiasis, Diabetes Insipidus, Edema, Hypertensive, Premenstrual tension with edema, Toxemia of pregnancy

Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) from the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. Ordinarily, the sodium-chloride symporter transports sodium and chloride in the lumen into the epithelial cell lining the distal convoluted tubule. The power for this is provided by means of a sodium gradient established by sodium-potassium ATPases on the basolateral membrane. After sodium has entered the cell, it is hauled out to the basolateral interstitium through the sodium-potassium ATPase, causing an increase in the osmolarity of the interstitium, thus establishing an osmotic gradient for water reabsorption. By blocking the sodium-chloride symporter, hydrochlorothiazide effectively lowers the osmotic gradient and water reabsorption through the nephron.

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How to use hydrochlorothiazide

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in smaller or larger quantities or for longer than suggested. Hydrochlorothiazide is taken once every day. Follow your doctor’s dosing instructions . Call your health care provider if you have nausea or ongoing vomiting, or whether you are sweating more than usual. It is simple to become dehydrated while taking this medicine, which can cause blood pressure and a imbalance.

You might need medical evaluations and blood pressure be checks when using hydrochlorothiazide. Your blood and urine both could be analyzed if you’ve been vomiting or are dehydrated. Inform the physician ahead of time that you are using hydrochlorothiazide if you need surgery. You may want to stop using the medication for a short moment.

Keep using this medication. High blood pressure often has no signs. You might want to use blood pressure medicine for the remainder of your life.

Side Effects

  • sexual dysfunction (impotence)
  • sore throat with fever
  • dizziness
  • cramps
  • thirst
  • vomiting
  • stomach pain
  • headache
  • constipation
  • diarrhea
  • loss of appetite
  • nausea
  • severe skin rash with peeling skin
  • difficulty breathing or swallowing
  • muscle weakness
  • unusual bleeding or bruising
  • hair loss

Hydrochlorothiazide (HCTZ)