Imipramine Hydrochloride

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Brand Names
Tofranil, Tofranil-PM

Imipramine hydrochloride Information

Imipramine is a tricyclic antidepressant. Imipramine affects chemicals in the brain which could be unbalanced in people with depression.Imipramine is used in the treatment of symptoms of melancholy. Imipramine is sometimes used to treat bed-wetting in kids ages 6 months and older.Imipramine may also be utilized for purposes.

Used for treatment: Adhd, Bulimia Nervosa, PTSD, Pain, Neuropathic, Panic Disorders

Imipramine operates by inhibiting the neuronal reuptake of the neurotransmitters norepinephrine and dopamine. It binds the sodium-dependent serotonin transporter and sodium-dependent norepinephrine transporter preventing or diminishing the reuptake of norepinephrine and serotonin by nerve cells. Depression has been associated with a lack of stimulation of this post-synaptic neuron by norepinephrine and serotonin. Slowing the reuptake of these hormones increases their concentration in the synaptic cleft, which is considered to contribute to relieving symptoms of depression. Along with significantly inhibiting neurotransmitter re-uptake, imipramine triggers down-regulation of cerebral cortical beta-adrenergic receptors and sensitization of both post-synaptic serotonergic receptors with chronic use. This contributes to improved serotonergic transmission.

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How to use imipramine hydrochloride

Follow all directions on your prescription label. Your doctor may change your dose. Do not use this medicine in bigger or smaller amounts or for longer than advised. Inform the physician ahead of time that you’re currently using imipramine should you require surgery. You might have to stop using the medicine for a short while. It might take around 3 months until your symptoms improve. Keep using the medication and tell your physician if your symptoms don’t improve. Call your doctor if they get worse, or if your symptoms do not improve.

You should not quit using imipramine. About tapering your own dose, follow your physician’s instructions. Store at room temperature away from moisture, heat, and lighting.

Side Effects

  • dry mouth
  • excitement or anxiety
  • weight loss or gain
  • constipation
  • changes in sex drive or ability
  • frequent urination
  • nightmares
  • confusion
  • nausea
  • weakness or tiredness
  • excessive sweating
  • sun sensitivity
  • drowsiness
  • blurred vision
  • difficulty urinating


Other drugs and medications that slow the brain’s processes, such as alcohol, barbiturates, benzodiazepines, by way of example, lorazepam, diazepam, temazepam, oxazepam, clonazepam, zolpidem, and narcotics, may increase the effect of imipramine on the brain. Reserpine, given to patients can lead to agitation and nervousness. For example, isocarboxazid, phenelzine, tranylcypromine, and procarbazine, because high fever, convulsions and death can occur TCAs shouldn’t be used with monoamine oxidase inhibiting drugs.

Blood levels that are imipramine can boost by lowering elimination of imipramine and potentially cause imipramine- side effects. Include methylphenidate, flecainide, quinidine, propafenone, and fluoxetine.