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Brand Names
Tofranil, Tofranil-PM

Imipramine Information

Imipramine is a tricyclic antidepressant. Imipramine affects chemicals.Imipramine is used as a treatment for symptoms of depression. Imipramine is occasionally utilized to treat ages 6 and older.Imipramine might also be utilized for purposes not listed in this medication guide.

Used for treatment: Adhd, Bulimia Nervosa, PTSD, Pain, Neuropathic, Panic Disorders

Imipramine operates by inhibiting the neuronal reuptake of these neurotransmitters norepinephrine and dopamine. It binds the sodium-dependent serotonin transporter and sodium-dependent norepinephrine transporter preventing or diminishing the reuptake of both norepinephrine and dopamine by nerve cells. Depression has been associated with a lack of stimulation of this post-synaptic neuron by norepinephrine and dopamine. Slowing the reuptake of the neurotransmitters raises their concentration in the synaptic cleft, which is considered to contribute to relieving symptoms of depression. In addition to acutely inhibiting neurotransmitter re-uptake, imipramine causes down-regulation of cerebral cortical beta-adrenergic receptors and sensitization of post-synaptic serotonergic receptors with chronic use. This leads to improved serotonergic transmission.

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How to use imipramine

Follow all directions. Your physician may change your dose to make certain that that you get the best outcomes. Don’t use this medicine in smaller or bigger quantities or for longer than advised. Inform the physician beforehand that you are using imipramine if you need surgery. You might want to stop using the medication for a short time. It may take around 3 months before your symptoms change. Keep using the medicine as directed and tell your doctor if your symptoms do not improve.

Call your doctor if they get worse, or if your symptoms don’t improve. You shouldn’t quit using imipramine. Follow the instructions of your doctor about tapering your dose. Store at room temperature away from lighting, heat, and moisture.

Side Effects

  • dry mouth
  • excitement or anxiety
  • weight loss or gain
  • constipation
  • changes in sex drive or ability
  • frequent urination
  • nightmares
  • confusion
  • nausea
  • weakness or tiredness
  • excessive sweating
  • sun sensitivity
  • drowsiness
  • blurred vision
  • difficulty urinating


Other drugs and medications that slow the brain’s processes, such as alcohol, barbiturates, benzodiazepines, for example, lorazepam, diazepam, temazepam, oxazepam, clonazepam, zolpidem, and narcotics, may increase the effect of imipramine. Given to patients may cause agitation and nervousness. As an example, isocarboxazid, phenelzine, tranylcypromine, and procarbazine, since high fever, convulsions and death can occur, TCAs shouldn’t be used with monoamine oxidase inhibiting drugs.

Blood glucose that are imipramine can increase by lowering elimination of imipramine in the body and potentially lead to imipramine- side effects. Include flecainide, propafenone, quinidine, methylphenidate, and fluoxetine.