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Lamotrigine Information

Lamotrigine is a anti-epileptic medication, also called an anticonvulsant.Lamotrigine is used either alone or in conjunction with other medicines to treat seizures in adults and kids. Lamotrigine is also used to delay mood episodes in adults with bipolar illness .The immediate-release Type of lamotrigine When it’s given as part of a mix of seizure drugs can be utilised in children. However, this form shouldn’t be utilised as a medication in a young child or adolescent who is younger than 16 years old.

The extended-release Type of lamotrigine Is for use only in adults and children who are at least 13 years of age. Lamotrigine may also be utilized for purposes not listed in this medication guide.

Used for treatment: Acute Bipolar Depression, Bipolar I Disorder, Partial Onset Seizures, Generalized seizure, Primary Generalized tonic-clonic seizure

One suggested mechanism of action of Lamotrigine, the significance of which remains to be established in people, involves an effect on sodium channels. At vitro pharmacological studies indicate that lamotrigine inhibits voltage-sensitive sodium stations and/or calcium channels, thus stabilizing neuronal membranes and consequently modulating presynaptic transmitter release of excitatory amino acids (e.g., glutamate and aspartate). Studies on lamotrigine reveal binding to sodium channels similar to local anesthetics.

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How to use lamotrigine

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in smaller or larger amounts or for longer than advised. Taking too much lamotrigine may raise your risk of a severe life-threatening skin rash. You might require blood tests that will help your physician make certain you’re taking the ideal dose of lamotrigine. Extended-release lamotrigine could be used for requirements that were various than lamotrigine can be used for.

Always check your refills to make sure to have received the right dimensions, colour, and shape of pill. Ask the pharmacist if you have any questions. Carefully follow your doctor’s instructions concerning dosage and the timing of your medicines, should you change to lamotrigine from another seizure medication. Read drug guides, all info, and instruction sheets supplied to you.

Ask your physician or pharmacist if you have some questions. Don’t crush, chew, or split the regular or the extended-release pill. Swallow it whole. Do not consume the orally disintegrating tablet whole. Put it and move it around in your mouth. Permit the tablet to dissolve in your mouth. Many times as the pill dissolves. If desired, you might drink liquid to simply consume the dissolved pill. You may either chew it, or swallow it whole with a glass of plain water and then swallow it , to take the chewable dispersible tablet.

You can also set the pill and let it disperse in the liquid for around 1 minute. Gently swirl the liquid and then swallow all of the mix immediately. Don’t store it for later usage. Do not stop using lamotrigine even in case you’re feeling fine. Stopping suddenly may cause increased seizures. Follow the directions of your doctor about tapering your dose. Wear a medical alert tag or carry an ID card stating that you take lamotrigine.

Any medical care provider who treats you ought to be aware that you take seizure medication. This medication may enable you to have a false positive drug screening evaluation. If you give a urine sample for drug screening, tell the lab staff which you’re taking lamotrigine. Utilize lamotrigine to get the maximum benefit. Take your prescription refilled before you run out of medicine completely.

Side Effects

  • hives
  • painful sores in your mouth or around your eyes
  • blurred or double vision
  • confusion
  • new or worse depression
  • stiff neck
  • rash
  • unusual sensitivity to light
  • acting aggressive, being angry, or violent
  • a skin rash
  • feeling agitated or restless
  • headache
  • increase your dose of lamotrigine faster than prescribed.
  • fever
  • rash
  • drowsiness
  • dry mouth
  • take a higher starting dose of lamotrigine than your doctor prescribed
  • panic attacks
  • unusual bruising or bleeding
  • other unusual changes in behavior or mood
  • swollen lymph glands
  • yellowing of your skin or the white part of your eyes
  • abdominal pain
  • lack of coordination
  • take lamotrigine while taking valproate [Depakene (valproic acid) or Depakote (divalproex sodium)]
  • sleepiness
  • blistering or peeling of your skin
  • new or worse anxiety
  • frequent infections
  • chills
  • back pain
  • tiredness
  • tremor
  • new or worse irritability
  • thoughts about suicide or dying
  • nausea, vomiting
  • nausea
  • swelling of your face, eyes, lips, or tongue
  • insomnia
  • dizziness
  • an extreme increase in activity and talking (mania)
  • attempt to commit suicide
  • weakness, fatigue
  • fever
  • vomiting
  • trouble sleeping (insomnia)
  • headache
  • fever
  • acting on dangerous impulses
  • severe muscle pain
  • muscle pains


Lamotrigine can interact with valproic acid. A 3-week period cans decrease over, when lamotrigine is initiated in patients receiving valproic acid. This may result in loss of seizure control. Valproic acid increases lamotrigine levels. The risk of skin rash may be increased by blending lamotrigine. There may be a greater prevalence of dizziness and blurred vision in patients receiving carbamazepine. The mechanism of this interaction is unclear.

Estrogen including oral contraceptives, phenobarbitol, primidone, phenytoin, and rifampin reduce the blood levels of lamotrigine by 40 percent-50 percent by increasing the breakdown of lamotrigine. This may result in reduced efficacy if the dose of lamotrigine is not adjusted.

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