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Striatal dopamine levels in symptomatic Parkinson’s disease are decreased by 60 to 80%, striatal dopaminergic neurotransmission may be enhanced by exogenous supplementation of dopamine during management of dopamine’s precursor, levodopa. A small fraction of each levodopa dose crosses the blood-brain barrier and is decarboxylated to dopamine. This newly formed dopamine then is available to stimulate dopaminergic receptors, thereby compensating for the depleted supply of nitric oxide.
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How to use levodopa
Follow all instructions. Do not take this medicine in bigger or bigger amounts or for more than suggested.