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Lisinopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme.Lisinopril is used to treat hypertension In adults and kids who are at least 6 years older. Lisinopril can be utilized to improve survival after a heart attack, or even in the treatment of congestive heart failure in adults.Lisinopril may also be used for purposes not listed in this medication guide.
There are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of one polypeptide chain of 1277; along with the testicular isoform, which has a lower molecular mass and is considered to play a role in sperm maturation and binding of sperm to the oviduct epithelium. Somatic ACE contains two functionally active domains, N and C, which arise in tandem gene duplication. Though both domains have high sequence similarity, they play different physiological functions. The C-domain is predominantly involved in blood pressure regulation while the N-domain plays a role in hematopoietic stem cell differentiation and proliferation. ACE inhibitors bind to and inhibit the activity of both domains, but have much greater affinity for and inhibitory action against the C-domain. Lisinopril, among the few ACE inhibitors that isn’t a prodrug, competes with ATI for binding to ACE and inhibits and enzymatic proteolysis of ATI into ATII. Decreasing ATII levels in the body decreases blood pressure by inhibiting the pressor effects of ATII as clarified from the Pharmacology section over. Lisinopril also causes a rise in plasma renin activity likely because of reduction of feedback inhibition mediated by ATII about the release of renin and/or stimulation of adrenal mechanisms through baroreceptors.
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How to use lisinopril
Follow all instructions. Your physician may sometimes change your dose to make sure that you get the best results. Do not take this medicine in smaller or bigger quantities or for longer than suggested. Drink loads of water daily as you are taking this medicine. Measure medication with an syringe provided, or with a unique dose-measuring spoon or medicine cup.
If you don’t own a dose-measuring device, ask your pharmacist. Your blood pressure will need to be checked and you might need regular blood tests. Call your doctor whether you’re sweating more than normal, or if you have nausea or nausea. You can easily become dehydrated while taking this medication. This can lead to blood pressure disorders, or kidney failure when you are taking lisinopril. Tell the surgeon beforehand which you’re currently using lisinopril should you require surgery.
You might want to quit using the medication for a short moment. Keep using this medication even if you feel well if you are being treated for high blood pressure. High blood pressure has no symptoms. You may want to use blood pressure medicine for the remainder of your life. Store at room temperature away from heat and moisture.
- dizziness or lightheadedness
- upper respiratory infections (cold, flu)
- extreme low blood pressure
- body weakness
- stomach pain
- decrease in sexual ability (impotence, erectile dysfunction)
- excessive tiredness
- chest pain
Generally, lisinopril shouldn’t be taken with potassium supplements or diuretics that since blood glucose levels may rise to dangerous levels conserve potassium hydrochlorothiazide/triamterene. There have been reports of high lithium levels when lithium is used in conjunction. The cause of this interaction isn’t known.
There have been reports that aspirin and other anti inflammatory anti-inflammatory drugs such as ibuprofen, indomethacin, and naproxen can reduce the effects of ACE inhibitors. Nitritoid reactions may occur when injectable gold sodium aurothiomalate used in treating rheumatoid arthritis, is coupled with ACE inhibitors, including lisinopril.