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Brand Names
Alavert, Claritin

Loratadine Information

Loratadine is an antihistamine that reduces the effects of chemical histamine in the body. Histamine can produce symptoms of itching, sneezing , watery eyes, and nose.Loratadine is used to treat itching, runny nose, watery eyes, hives, skin rash, and sneezing, and other cold or allergy symptoms.Loratadine is also utilized in the treatment of skin problems and itching in people with chronic skin reactions.Loratadine may also be used for purposes not listed in this medication guide.

Used for treatment: Pruritus, Seasonal Allergic Rhinitis

Loratadine competes with free histamine and displays particular, selective peripheral H1 antagonistic activity. This blocks the action of endogenous histamine, which then contributes to temporary relief of the negative symptoms (eg. Nasal congestion, watery eyes) caused by histamine. Loratadine has low affinity for cholinergic receptors and does not exhibit any considerable alpha-adrenergic blocking action in-vitro. Loratadine also seems to suppress the release of histamine and leukotrienes from animal mast cells, and also the release of leukotrienes from human lung fragments, even though the clinical importance of this is unknown.

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How to use loratadine

Use exactly as directed on the label, or as prescribed by your physician. Do not use in bigger or smaller amounts or for longer than advised. Cold or allergy medication is usually obtained only for a brief time until the symptoms clear up. Do not give this medication. Before giving a child a cold or cough medicine, always ask a physician. Death may occur from the misuse of cough and cold medications in children. Loratadine is usually taken once every day. Follow your doctor’s instructions.

Don’t crush, chew, or break the normal tablet. Swallow the pill complete. Measure liquid medicine with an dosing syringe provided, or using a special dose-measuring spoon or medicine cup. If you do not own a dose-measuring device, ask your pharmacist for one. The chewable tablet should be chewed before you swallow it. To take the orally disintegrating tablet :

  • Maintain the pill in its blister pack until you are prepared to take it.

    Open the bundle and then peel back the foil. Do not push a tablet through the foil or you can damage the tablet.

  • Use dry hands to remove the tablet and place it in your mouth.
  • Do not swallow the pill whole. Let it dissolve in your mouth. You might drink liquid to help swallow the pill that is dissolved, if wanted.

Telephone your physician if your symptoms do not improve, or if they get worse.

Store at room temperature away from heat and moisture.


By inhibiting the elimination of loratadine the blood concentration of loratadine increases. This may result in adverse events from loratadine. St. John’s wort, carbamazepine , and rifampin reduce blood levels of loratadine.