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Losartan potassium Information
Losartan is an angiotensin II receptor antagonist. Losartan prevents blood vessels from narrowing, which improves blood circulation and lowers blood pressure.Losartan is used to treat hypertension In adults and children who are at least 6 years old. It’s also utilised to lower the probability of stroke in individuals. Losartan can be used to slow long-term kidney damage in individuals.Losartan may also be used for purposes.
Losartan competitively inhibits the binding of angiotensin II into AT1 in several tissues such as vascular smooth muscle and the adrenal glands. Losartan is metabolized to its active metabolite, E-3174, which is 10 to 40 times more potent than losartan and acts as a non-competitive AT1 antagonist. Inhibition of angiotensin II binding to AT1 inhibits its AT1-mediated vasoconstrictive and aldosterone-secreting effects and results in decreased vascular resistance and blood pressure. Losartan is 1,000 times more selective for AT1 compared to AT2. Inhibition of aldosterone secretion may increase sodium and water excretion while decreasing potassium excretion. Losartan is effective for reducing blood pressure and might be used to treat essential hypertension, left ventricular hypertrophy and diabetic nephropathy.
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How to use losartan potassium
Follow all instructions on your prescription label. Your physician may change your dose to make certain you get the best outcomes. Don’t take this medicine in larger or smaller quantities or for longer than suggested. You may take losartan with or without food. Call your health care provider if you have nausea or vomiting, or if you are sweating more than normal.
It is simple to become infected while taking this medication, which can cause a serious electrolyte imbalance and also severely low blood pressure. Your blood pressure will need to get checked often. You might need blood and urine tests in your physician’s office. It could take 3 to 6 months of using this medicine prior to your blood pressure is under control. For optimum results, continue using the medication as directed.
Speak to your doctor if your condition doesn’t improve after 3 months of treatment. Keep using this medicine even in the event that you feel well, if you are being treated for high blood pressure. High blood pressure often has no symptoms. You might want to use blood pressure medication for the remainder of your life. Store at room temperature away from heat, moisture, and lighting.
Side Effects
- “colds” (upper respiratory infection)
- dizziness
- stuffy nose
- back pain
Interactions
Losartan may increase levels of blood potassium, which can lead to heart issues. Concomitant use of other substances or drugs that increase blood-such like potassium supplements, diuretics, or salt substitutes containing potassium may lead to increases in serum potassium. Combining losartan or other ARBs with drugs or with poor kidney function may result in reduced kidney function, including kidney failure.
These effects usually are reversible. The antihypertensive effect of losartan may be reduced by aspirin and other NSAIDs for example: ibuprofen, indomethacin, and naproxen. Mixing ARBs, reduces kidney function compared to each drug used, and ACE inhibitors, or aliskiren raises risk of hypotension, hyperkalemia and there’s no benefit on preventing end stage kidney illness or death. Losartan and Aliskiren should not be combined in individuals with diabetes or with renal impairment.
Increases in blood lithium levels and lithium ion have happened when hydrochlorothiazide or lithium and ARBa were united. Blood lithium levels must be tracked.