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Losartan Information
Losartan is an angiotensin II receptor antagonist. Losartan keeps blood vessels from narrowing, which improves blood circulation and lowers blood pressure.Losartan is used to treat hypertension In kids and adults that are at least 6 years old. It is also utilised to lower the chance of stroke in certain people. Losartan can be used to slow kidney damage in people.Losartan may also be used for purposes not listed in this medication guide.
Losartan competitively inhibits the binding of angiotensin II into AT1 in many tissues such as vascular smooth muscle and the adrenal glands. Losartan is metabolized to its active metabolite, E-3174, which is 10 to 40 times more potent than losartan and acts as a non-competitive AT1 antagonist. Inhibition of angiotensin II binding to AT1 inhibits its AT1-mediated vasoconstrictive and aldosterone-secreting effects and leads to decreased vascular resistance and blood pressure. Losartan is 1,000 times more selective for AT1 than AT2. Inhibition of aldosterone secretion may increase sodium and water excretion while reducing potassium excretion. Losartan is effective for reducing blood pressure and may be used to deal with essential hypertension, left ventricular hypertrophy and diabetic nephropathy.
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How to use losartan
Follow all instructions on your prescription label. Your doctor may change your dose. Don’t take this medication in smaller or larger amounts or for longer than recommended. You may take losartan with or without food. Call your doctor whether you’re sweating more than usual, or if you have ongoing vomiting or diarrhea. It is easy to become infected while taking this medication, which can result in blood pressure along with even a imbalance. Your blood pressure will need to get checked.
You may need other urine and blood tests at your physician’s office. It may take 3 to 6 weeks of using this medicine prior to your blood pressure is in check. For optimum results, continue using the medicine as directed. Talk to your doctor if your condition doesn’t improve after 3 weeks of treatment. If you are being treated for high blood pressure, continue using this medicine even in case you are feeling good. High blood pressure has no signs. You may need to use blood pressure medication for the remainder of your life.
Store at room temperature away from heat, moisture, and lighting.
Side Effects
- “colds” (upper respiratory infection)
- dizziness
- stuffy nose
- back pain
Interactions
Losartan may raise levels of blood glucose, which may lead to serious heart problems. Concomitant use of substances or other drugs that increase blood-such like potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium. Mixing other or losartan ARBs with nonsteroidal anti-inflammatory drugs in patients that are older, fluid-depleted, or with poor kidney function may result in kidney function, including kidney failure.
These effects usually are reversible. The antihypertensive effect of losartan may be decreased by aspirin and other NSAIDs such as: naproxen, indomethacin, and ibuprofen. ACE inhibitors mixing ARBs, or aliskiren raises risk of hypotension also reduces kidney function compared to each drug used and there is not any benefit on preventing end stage kidney disease or death. Aliskiren and losartan shouldn’t be united in patients with diabetes or with renal impairment.
Increases in blood lithium levels and lithium ion have happened when hydrochlorothiazide or ARBa ion and lithium were combined. Blood lithium levels must be monitored.