Metformin Hydrochloride

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Brand Names
Actoplus Met, Avandamet, Fortamet, Glucophage, Glucovance, Glumetza, Invokamet, Janumet, Jentadueto, Kazano, Kombiglyze XR, Metaglip, PrandiMet, Riomet

Metformin hydrochloride Information

Metformin is.Metformin is for people with type 2 diabetes. Metformin is utilized in conjunction with insulin or other medications, for treating type 1 diabetes but metformin is not.Metformin may also be used for purposes not listed in this medication guide.

Used for treatment: Polycystic Ovaries Syndrome, Type 2 Diabetes Mellitus

Metformin’s mechanisms of action differ from other classes of oral antihyperglycemic agents. Metformin reduces blood glucose levels by decreasing hepatic glucose production, reducing intestinal absorption of sugar, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization. These effects are mediated by the first activation by metformin of AMP-activated protein kinase (AMPK), a liver enzyme that plays a significant role in insulin signaling, whole body energy balance, and the metabolism of glucose and fats. Activation of AMPK is required for metformin’s inhibitory effect on the production of glucose by liver cells. Increased peripheral utilization of glucose may be due to improved insulin binding to insulin receptors. Metformin administration also increases AMPK activity in skeletal muscle. AMPK is known to cause GLUT4 deployment to the plasma membrane, leading to insulin-independent glucose uptake. The rare complication, lactic acidosis, is thought to be due to decreased liver uptake of serum lactate, one of the substrates of gluconeogenesis. In people who have healthy renal function, the slight surplus is simply removed. However, people who have severe renal impairment might collect clinically important serum lactic acid levels. Other conditions that may precipitate lactic acidosis include severe hepatic disease and acute/decompensated heart failure.

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How to use metformin hydrochloride

Follow all directions. Your doctor may change your dose to be certain you get the best results. Don’t use this medicine in bigger or smaller quantities or for longer than suggested. Some forms of metformin are obtained with the evening meal. Follow your doctor’s directions. Don’t crush, chew, or split an extended-release tabletcomputer. Your blood glucose will have to be checked and you may need additional blood tests in your doctor’s office.

Low blood sugar Can occur to everyone with diabetes. Symptoms include headache, appetite, sweating, confusion, nausea, irritability, or feeling. If you have low blood glucose, keep a supply of sugar with you. Sugar sources contain crackers, hard candy, fruit juice, crackers, and non-diet soda. Make certain your loved ones and close friends know how to help you. When you cannot eat or drink and have hypoglycemia, utilize a glucagon injection.

Your physician can prescribe a glucagon emergency injection kit and also tell you just how to utilize it. Check your blood sugar through times of anxiety, traveling, illness, operation or medical crisis, when you drink alcohol, or vigorous exercise or skip meals. Your glucose levels can affect along with your dosage needs can change. Don’t alter your medication dosage or program without your physician’s advice.

Metformin is part of a treatment plan which may include exercise, diet, weight management, and medical care that is special. Follow your doctor’s instructions. Your doctor may have you take extra vitamin B12 as you’re taking metformin. Store at room temperature away from heat, moisture, and lighting.

Side Effects

  • diarrhea
  • nausea
  • unusual muscle pain
  • feeling dizzy or lightheaded
  • upset stomach
  • unusual or unexpected stomach discomfort
  • feeling very weak, tired, or uncomfortable
  • suddenly developing a slow or irregular heartbeat
  • feeling cold
  • trouble breathing


By decreasing metformin’s elimination can raise the amount of metformin from the bloodstream by 40%. This may increase the frequency of side effects. Other along with Ioversol iodinated contrast media can decrease kidney function, which reduces removal of metformin. Metformin should be stopped 48 hours before and after. Steroids, Thiazide diuretics, estrogens, and blood sugar may increase and lessen the effect of metformin.

Patients must be carefully monitored for signs of low blood sugar, when these drugs are stopped. Alcohol consumption increases the effect of metformin on lactate production, increasing the risk of lactic acidosis.

Metformin – Anti-aging Drug – Human Trials 2016