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Mirtazapine hydrochloride Information
Mirtazapine is a antidepressant. Mirtazapine affects chemicals in the brain which could be unbalanced in individuals with depression.Mirtazapine is used as a treatment for major depressive disorder.Mirtazapine may also be used for purposes not listed in this medication guide.
Mirtazapine acts as an antagonist at central pre-synaptic alpha(2)-receptors, inhibiting negative responses to the presynaptic nerve and resulting in an increase in NE release. Blockade of heteroreceptors, alpha(2)-receptors contained in serotenergic neurons, enhances the release of 5-HT, increasing the connections between 5-HT and 5-HT1 receptors and leading to the anxiolytic effects of mirtazapine. Mirtazapine also acts as a weak antagonist in 5-HT1 receptors and as a potent antagonist at 5-HTtwo (particularly subtypes 2A and 2C) and 5-HT3 receptors. Blockade of these receptors might explain the lower prevalence of adverse effects such as stress, insomnia, and nausea. Mirtazapine also exhibits substantial antagonism at H1-receptors, resulting in sedation. Mirtazapine has no effects on the reuptake of either NE or even 5-HT and has only minimal activity at dopaminergic and muscarinic receptors.
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How to use mirtazapine hydrochloride
Follow all directions on your prescription label. Do not take this medicine in bigger or smaller amounts or for longer than suggested. Mirtazapine is usually taken once a day during pregnancy. Follow your doctor’s directions. Simply take mirtazapine’s pill kind . To take the orally disintegrating tablet computer:
- Maintain the tablet in its blister pack until you are all set to take it. Open the package and peel the foil back.
Do not push a tablet or you may damage the pill.
- Use dry hands to eliminate the tablet and put it on your mouth.
- Do not swallow the tablet whole. Let it dissolve in your mouth. You might drink liquid to assist swallow the pill if wanted.
It might take up to several weeks before your symptoms improve. Keep using the medicine and inform your doctor if your symptoms don’t improve after 4 months of treatment.
Do not quit using mirtazepine abruptly, or you may have unpleasant withdrawal symptoms. Consult your doctor the way to stop using mirtazepine.
Side Effects
- dry mouth
- abnormal dreams
- sleepiness
- increased appetite, weight gain
- dizziness
- constipation
Interactions
Mirtazapine adds to the sedating effects of alcohol and other medications which can cause sedation for example: the tricyclic class of antidepressants, the benzodiazepine class of drugs, the narcotic class of pain drugs and its derivatives antihypertensive medications, and some antihistamines. Fluvoxamine, ketoconazole and cimetidine may increase the levels of mirtazapine in the blood which might lead to increased side effects from mirtazapine.
Carbamazepine and phenytoin decrease the blood flow of mirtazapine by increasing the breakdown of mirtazapine in the liver. Mirtazapine shouldn’t be used with monoamine oxidase inhibiting drugs like phenelzine, procarbazine, selegiline, or tranylcypromine. Convulsions, high fever, and even death can occur from such combinations. Therefore, an interval of 14 days is recommended between quitting MAO inhibitor therapy and beginning vice versa, and mirtazapine.
If mirtazapine is combined with other medications that increase serotonin activity in the mind similar reactions may happen. Such drugs to prevent include tryptophan, sumatriptan, linezolid, fluoxetine, venlafaxine , lithium, tramadol, and St. John’s wort.