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Brand Names

Nortriptyline Information

Nortriptyline is a tricyclic antidepressant. Nortriptyline affects chemicals.Nortriptyline is used to treat symptoms of depression.Nortriptyline may also be used for purposes not listed in this medication guide.

Used for treatment: Acute Depressive Episode, Adhd, Irritable Bowel Syndrome

It is believed that nortriptyline either inhibits the reuptake of the neurotransmitter serotonin at the neuronal membrane or acts at beta-adrenergic receptors. Tricyclic antidepressants don’t inhibit monoamine oxidase nor do they influence dopamine reuptake.

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How to use nortriptyline

Follow all instructions. Your physician may sometimes change your dose. Do not take this medicine in bigger or smaller amounts or for longer than suggested. If you require surgery, inform the physician beforehand that you are using nortriptyline. You may want to quit using the medicine for a short while. Don’t quit using nortriptyline abruptly, or you might suffer withdrawal symptoms. Consult your doctor how to quit using nortriptyline.

It can take a few weeks before your symptoms change. Continue using the medicine as directed and tell your physician if your symptoms do not improve.

Side Effects

  • drowsiness
  • nausea
  • difficulty urinating
  • nightmares
  • weight gain
  • dry mouth
  • changes in sex drive
  • constipation
  • weakness
  • headache
  • dizziness
  • blurred vision
  • changes in heart rhythm
  • increased sweating


TCAs, including nortriptyline, shouldn’t be used simultaneously with a monoamine oxidase inhibitors such as tranylcypromine, isocarboxazid, phenelzine, and procarbazine due to the possibility of crises, convulsions, and death. Cimetidine can boost blood levels of nortriptyline from the blood by interfering with the metabolism of nortriptyline.

Increased levels of nortriptyline may potentially lead to unwanted effects. Include flecainide, propafenone, quinidine, and fluoxetine. Nortriptyline exaggerates the effects of other drugs and medications that slow the activity of the mind, such as alcohol, barbiturates, benzodiazepines, such as lorazepam, clonazepam, and diazepam, in addition to narcotics. When given to individuals taking 11, Reserpine, arouses the brain.

Mixing nortriptyline or other TCAs that block acetylcholine may cause constipation and even paralyze the gut. Elevations in blood pressure may happen if TCA’s are combined with clonidine.

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