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Brand Names
Di-Phen, Dilantin, Euthasol, Phenytek

Phenytoin Information

Phenytoin is an anti-epileptic drug referred to as an anticonvulsant. It works by slowing down impulses in the brain that cause seizures.Phenytoin is used to control seizures. Phenytoin does not take care of all kinds of seizures, and your doctor will ascertain if it is the right medication for you.Phenytoin may also be used for purposes.

Used for treatment: Complex Partial Seizures, Generalized Tonic-Clonic Seizures, Seizures

Phenytoin acts on sodium channels on the neuronal cell membrane, restricting the spread of seizure activity and reducing seizure propagation. By promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability brought on by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. Including the reduction of post-tetanic potentiation at synapses. Loss of post-tetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas.

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How to use phenytoin

Follow all instructions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Do not use. Telephone your doctor for a new prescriptionmedicine. Shake the oral suspension Well just until a dose is measured by you. Measure liquid medication with all the syringe provided, or with a special dose-measuring spoon or medicine cup.

If you don’t have a dose-measuring device, ask your pharmacist for one. While using phenytoin, you may need regular blood tests. When changing to another from one form of phenytoin, you might require a blood test. Go to your physician regularly. Don’t quit using phenytoin even in the event you’re feeling good, if you’re currently taking phenytoin to deal with migraines.

Stopping suddenly may cause migraines. About tapering your own dosage, follow the instructions of your doctor. If in treating your situation, this medication does not seem to function 13, tell your doctor. Wear a medical alert tag or take an ID card stating that you just take phenytoin. Ought to know that you take seizure drugs. Phenytoin may cause swelling in your teeth. Brush and floss your teeth and visit your dentist regularly to help stop this problem. Store at room temperature away from warmth, light, and moisture.

Side Effects

  • nervousness
  • confusion
  • rash
  • vomiting
  • problems with walking and coordination
  • tremor
  • nausea
  • dizziness
  • Softening of your bones (osteomalacia). This can cause broken bones.
  • headache
  • trouble sleeping
  • constipation
  • slurred speech


There are lots of drug interactions with phenytoin. Phenytoin can raise the metabolism of many drugs, reducing their levels within the body. Include: digoxin, carbamazepine, clonazepam, corticosteroids, cyclosporine, disopyramide, doxycycline, estrogens, oral contraceptives, paroxetine , quinidine, tacrolimus, theophylline, phenobarbital, valproic acid , and warfarin.

These medications can be interacted with by Phenytoin . In the latter case, the concentration of these drugs might increase. The effect may be unpredictable. Phenytoin’s metabolism may be affected by other medications. Drugs that toxicity and boost phenytoin blood levels include: acute alcohol intake, amiodarone , chlordiazepoxide, cimetidine , diazepam , dicumarol, disulfiram, estrogens, ethosuximide, fluoxetine, fluorouracil, fluvoxamine, isoniazid, methylphenidate, omeprazole, sertraline , tolbutamide, and trazodone .

Drugs which may decrease phenytoin levels and reduce effectiveness include carbamazepine, chronic alcohol abuse, reserpine, and sucralfate. The oral absorption of phenytoin can be lessened by any of these: antacids containing calcium, magnesium carbonate, or aluminum; calcium salts; or enteral feeding products. Separating the administration of enteral and phenytoin feeding products, antacids, or calcium salts by at least two hours will help avoid this interaction.

Nursing Pharmacology Dilantin