Pioglitazone Hydrochloride

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Brand Names

Pioglitazone hydrochloride Information

Pioglitazone is an oral diabetes medication which helps control blood sugar levels.Pioglitazone is for individuals with type 2 diabetes. Pioglitazone is not for curing type 1 diabetes.Pioglitazone may also be used for purposes not listed in this medication guide.

Used for treatment: Type 2 Diabetes Mellitus

Pioglitazone functions as a selective agonist in Peroxisome Proliferator Activated Receptor Gamma (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors increases the transcription of insulin-responsive genes involved in the control of glucose production, transportation, and use. In this manner, pioglitazone both enriches tissue sensitivity to insulin and lowers the generation of sugar via the liver (hepatic gluconeogenesis). Therefore, insulin resistance associated with type 2 diabetes mellitus is improved without an increase in insulin secretion by pancreatic cells.

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How to use pioglitazone hydrochloride

Follow all directions on your prescription label. Your physician may change your dose to be certain to have the best outcomes. Don’t take this medication in larger or smaller amounts or for longer than recommended. Pioglitazone is usually taken once per day. You will take the medication with or without meals. Your blood glucose will have to be checked often, and blood tests may be needed by you in your doctor’s office.

Low blood sugar Can occur. Symptoms include headache, hunger, sweating, light skin, irritability, dizziness or difficulty concentrating. Maintain a supply of sugar with you in the event you have low blood glucose. Sugar sources contain soda, hard candy, crackers, crackers, and fruit juice. Make sure your family and close friends know how to help you. In case you can not drink or eat and have hypoglycemia that is severe, use a glucagon injection.

A glucagon emergency injection kit can be prescribed by your doctor and also tell you how you can utilize it. Assess your blood sugar during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or when you consume alcohol or skip meals. These things can influence your glucose levels and your dose needs may change. Don’t change your medication dosage or program without your physician’s advice.

Utilize pioglitazone frequently to get the maximum benefit. Pioglitazone is only part of a therapy plan that may incorporate exercise, diet, weight management, blood sugar testing, and medical care that is specific. Follow your doctor’s instructions. Store at room temperature away from lighting, heat, and moisture.

Side Effects

  • sore throat
  • headache
  • muscle pain
  • cold-like symptoms (respiratory tract infection)
  • sinus infection


Gemfibrozil reduces the breakdown by increasing blood levels specific liver enzymes and side effects of Actos of Actos. When combined with gemfibrozil or other drugs that decrease Actos’ dose should not exceed 15 mg daily. Conversely, the breakdown of Actos increases by the liver.

How Does Pioglitazone Work In The Body?