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Actos
Pioglitazone Information
Pioglitazone is.Pioglitazone is for people with type 2 diabetes. For curing type 1 diabetes, pioglitazone is not.Pioglitazone may also be used for purposes not listed in this medication guide.
Pioglitazone acts as a selective agonist in Peroxisome Proliferator Activated Receptor Gamma (PPAR) in target tissues for insulin action like adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors increases the transcription of insulin-responsive genes involved in the control of glucose production, transportation, and utilization. This way, pioglitazone both enhances tissue sensitivity to insulin and lowers the production of sugar through the liver (hepatic gluconeogenesis). Thus, insulin resistance associated with type 2 diabetes mellitus is improved without an increase in insulin secretion by pancreatic cells.
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How to use pioglitazone
Follow all instructions. Your doctor may change your dose. Do not take this medicine in smaller or larger amounts or for longer than recommended. Pioglitazone is usually taken once daily. You may take the medicine with or without food. Your blood glucose will need to be checked and blood tests may be needed by you in your doctor’s office. Low blood sugar Can occur.
Symptoms include headache, hunger, sweating, light skin, irritability, dizziness or trouble concentrating. Maintain a supply of glucose with you in the event you have low blood sugar. Sugar sources include non-diet soda, hard candy, crackers, raisins, and fruit juice. Be certain your loved ones and close friends know how to assist you.
If you have severe hypoglycemia and cannot drink or eat, utilize a glucagon injection. Your doctor can prescribe a emergency injection kit and tell you just how you can use it. Assess your blood glucose during times of stress, travel, illness, medical or medical crisis, if you consume alcohol, or vigorous exercise or skip meals. These things can affect your glucose levels along with your dose needs might also change.
Do not alter your medication dosage or program without your physician’s advice. Utilize pioglitazone often to get the maximum benefit. Pioglitazone is just part of a therapy system which may have medical attention, exercise, weight management, blood glucose testing, and diet. Follow your doctor’s instructions carefully. Store at room temperature away from heat, moisture, and light.
Side Effects
- sore throat
- headache
- muscle pain
- cold-like symptoms (respiratory tract infection)
- sinus infection
Interactions
Gemfibrozil lowers the break down by increasing blood levels liver enzymes and side effects of Actos of Actos. Actos’ maximum dose should not exceed 15 mg per day when combined with gemfibrozil or other drugs that reduce. Conversely, rifampin increases Actos’ breakdown from the liver, reducing blood levels and possibly the effects of Actos.