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Brand Names

Piroxicam Information

Piroxicam is a nonsteroidal anti-inflammatory drug . This medicine works by reducing substances in the body that cause inflammation and pain.Piroxicam is used to deal with swelling or pain .Piroxicam might also be utilized for purposes not listed in this medication guide.

Used for treatment: Ankylosing Spondylitis, Synovitis of osteoarthritis

The antiinflammatory effect of Piroxicam can result from the reversible inhibition of both cyclooxygenase, causing the peripheral inhibition of prostaglandin synthesis. The prostaglandins are produced by means of an enzyme called Cox-1. Piroxicam blocks the Cox-1 receptor, leading to the disruption of production of prostaglandins. Piroxicam additionally inhibits the migration of leukocytes to sites of inflammation and prevents the formation of thromboxane A2, an aggregating agent, by the platelets.

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How to use piroxicam

Follow all directions. Your physician may sometimes change your dose. Do not take this medication in larger quantities or for longer than recommended. Use the lowest dose that is effective in treating your condition. It could take up to 2 weeks until your symptoms improve. Continue using the medication and inform your health care provider if your symptoms don’t improve.

Regular tests may be needed by you, in the event you use this medication long-term. Store at room temperature away from moisture and heat. Read instruction sheets, drug guides, and all info provided to you. Consult your physician or pharmacist if you have any queries.

Side Effects

  • headache
  • dizziness
  • nervousness
  • diarrhea
  • heartburn
  • indigestion
  • drowsiness
  • stomach pain
  • constipation
  • gas


The blood levels of lithium can increase by reducing the excretion of lithium. Increased levels of lithium can lead to lithium toxicity. Piroxicam may lower the blood pressure lowering effects of blood pressure medications. This might happen because prostaglandins play a part in the regulation of blood pressure. Combining NSAIDs such as piroxicam using angiotensin receptor blockers or angiotensin converting enzyme ACE) inhibitors in patients who are elderly, volume-depleted, or with poor kidney function may result in reduced kidney function, including kidney failure.

These effects are reversible. That the blood levels of aminoglycoside or methotrexate may grow, presumably because the elimination of aminoglycosides or methotrexate from the body is diminished, when piroxicam is utilized in conjunction with methotrexate or aminoglycoside antibiotics. This may lead to methotrexate- or – aminoglycoside- associated side effects. People taking anticoagulants or blood thinners, as an example, warfarin,, should prevent piroxicam since the blood also disrupts, and excessive blood loss may result in bleeding.

Alcohol intake may increase the chance of developing stomach ulcers when taking piroxicam or other NSAIDs.