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Prednisone acetate Information
Prednisone is a steroid. Prednisone prevents the discharge of substances. Prednisone reduces the immune system.Prednisone is used as an immunosuppressant medication or an anti-inflammatory. Prednisone treats many different conditions such as arthritis, skin conditions, ulcerative colitis, allergic disorders, lupus, psoriasis, or even breathing disorders.Prednisone may also be used for purposes.
Prednisone is a glucocorticoid receptor agonist. It is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the website of inflammation, disturbance in the function of mediators of inflammatory response, suppression of humoral immune responses, and decrease in edema or scar tissues. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Prednisone can stimulate secretion of different elements of gastric juice. Suppression of the creation of corticotropin can lead to suppression of endogenous corticosteroids. Prednisone has minor mineralocorticoid activity, whereby entry of sodium into cells and loss of intracellular potassium is stimulated. This is very evident in the liver, where rapid ion exchange contributes to sodium retention and hypertension.
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How to use prednisone acetate
Follow all directions. Your physician may change your dose. Don’t take this medicine in smaller or bigger amounts or for longer than suggested. Take with meals. Your dose needs can change when you have any unusual stress such as illness, a significant illness or illness, or if you have a medical emergency or surgery. Do not alter your medication dose or schedule without your doctor’s advice.
Measure liquid medication with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. Don’t crush, chew, or split a tabletcomputer. You might require blood tests, when utilizing prednisone. Your blood pressure may have to be checked. This medication can cause results with certain evaluations.
You should not stop using prednisone. About tapering your dose, follow your doctor’s instructions. Wear a medical alert tag or carry an ID card saying that you take prednisone. Should know that you’re currently using a steroid. Store at room temperature away from moisture and heat.
Side Effects
- joint and muscle pain
- decreased immune system function
- dizziness
- blurred vision
- retention of fluid resulting in swelling
- abnormal distribution of body fat
- electrolyte imbalances
- headache
- inappropriate happiness
- acne
- slow healing
- decreased bone density
- hypertension
- depression
- nausea
Interactions
Prednisone interacts with medications include: Prednisone might interact with phenytoin and estrogens. Estrogens may reduce the activity of enzymes in the liver that breakdown the active form of prednisone, prednisolone. As a result, the degree of prednisolone from the body can increase and lead to side effects that are more common. Phenytoin increases the action of enzymes in the liver that can reduce the efficacy of prednisone and break prednisone down.
If phenytoin has been accepted, an increased dose of prednisone may be required. The risk of hypokalemia increases when corticosteroids are combined with drugs that reduce potassium levels, resulting in serious side effects like heart arrhythmias, heart enlargement and heart failure. Corticosteroids may increase or decrease the reaction warfarin.
Consequently, warfarin therapy should be monitored. The answer to diabetes medication may be lowered since increases blood glucose. Prednisone may raise the risk of tendon rupture in patients treated with fluoroquinolone form antibiotics. Cases of fluoroquinolones include ciprofloxacin and levofloxacin. The elderly are especially at risk and tendon rupture may occur during or following treatment with fluoroquinolones. Mixing aspirin, ibuprofen or other anti inflammatory anti-inflammatory brokers with corticosteroids increases the chance of stomach related side effects like ulcers.
Barbiturates, carbamazepine, rifampin and other medications that increase the action of liver enzymes that breakdown prednisone may reduce blood levels of prednisone. Additionally, ketoconazole, itraconazole, ritonavir, indinavir, macrolide antibiotics such as erythromycin, and other medications that reduce the action of liver enzymes that breakdown prednisone may raise blood levels of prednisone.