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Benemid, Polycillin-PRB
Probenecid Information
Probenecid helps your body pass uric acid out via the urine, which reduces the levels of uric acid in the human body.Probenecid is used in the treatment of gout and gouty arthritis. Probenecid is occasionally given as well as penicillin antibiotics to make them more successful.Probenecid may also be used for functions not listed in this medication guide.
Probenecid inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and diminishing serum glucose levels. Probenecid can also reduce plasma binding of urate and inhibit renal secretion of uric acid in subtherapeutic concentrations. The mechanism where probenecid inhibits renal tubular transport isn’t understood, but the drug may inhibit transport enzymes that need a source of high energy phosphate bonds and/or nonspecifically interfere with substrate accessibility to protein receptor sites on the kidney tubules.
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How to use probenecid
Take this medicine exactly as prescribed by your doctor. Do not simply take it in larger quantities or for longer than recommended. Follow the directions. Drink loads of water to avoid kidney stones when you’re taking probenecid. Probenecid may be just part of an entire program of therapy that has other medications diet, and vitamin supplements.
Follow the directions of your doctor. To be sure this medicine isn’t causing effects, urine or your blood might want to be tested on a regular basis. Can not miss any scheduled appointments. If you are taking probenecid together using an antibiotic, be sure to read the medicine guide or individual instructions supplied with each of your medicines.
Do not change medication schedule or your doses without guidance from your physician. If you will need to have any kind of surgery, tell the surgeon beforehand which you’re taking probenecid. This medicine may affect your body’s reaction. Store probenecid in room temperature away from heat and moisture.
Side Effects
- worsening of a gouty arthritis attack
- itching
- headache
- nausea
- vomiting
- increased urination
- hair loss
- skin rash
- fever
- dizziness
- sore gums
- loss of appetite
Interactions
Probenecid blocks excretion of some drugs and, therefore, may increase side effects and blood levels of methotrexate and nonsteroidal antiinflammatory drugs. Aspirin may reduce the activity of probenecid through mechanisms that are unknown.