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Repaglinide Information
Repaglinide is a oral diabetes medication which helps control blood sugar levels by causing the pancreas to make insulin.Repaglinide is used jointly with diet and exercise to treat type 2 diabetes. Diabetes medications are sometimes utilized in combination with repaglinide if needed.Repaglinide may also be used for purposes not listed in this medication guide.
Repaglinide activity depends upon the existence working ОІ cells and sugar. In contrast to sulfonylurea insulin secretatogogues, repaglinide has no impact on insulin release in the absence of glucose. Instead, it potentiates the effect of extracellular sugar on ATP-sensitive potassium channel and has small effect on insulin levels between meals and overnight. Therefore, repaglinide is significantly more effective at reducing postprandial blood glucose levels than fasting blood sugar levels and requires a longer period of therapy (approximately 1 month) before declines in fasting blood sugar are detected. The insulinotropic effects of repaglinide are greatest at intermediate glucose levels (3 to 10 mmol/L) and it does not increase insulin release already stimulated by elevated glucose concentrations (greater than 15 mmol/L). Repaglinide appears to be selective for pancreatic cancer ОІ cells and does not appear to affect coronary or cardiac muscle or thyroid tissue.
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How to use repaglinide
Follow all directions. Your doctor may change your dose to make sure to get the best outcomes. Do not take this medicine in smaller or bigger quantities or for longer than suggested. Repaglinide is taken two to four times each day, within 30 minutes before eating a meal. Follow your doctor’s directions. Don’t simply take your dose of repaglinide, if you skip a meal.
Wait until your next meal. Your blood glucose will have to be checked frequently, and other blood tests may be needed by you at the office of your doctor. Low blood sugar may happen to everybody who has diabetes. Symptoms include headache, hunger, sweating, confusion, nausea, irritability, or feeling shaky. In case you have low blood glucose, keep a supply of sugar with you.
Sugar resources include crackers, hard candy, fruit juice, raisins, and non-diet soda. When you cannot eat or drink and have severe hypoglycemia, use a glucagon injection. Your physician can prescribe a glucagon emergency injection kit and explain to you how you can utilize it. Also watch for signs of high blood sugar such as increased thirst, increased urination, hunger, dry mouth, and deep breath odor, drowsiness, dry skin, blurred vision, along with weight loss.
Assess your blood glucose carefully during times of anxiety, travel, illness, medical or medical crisis, vigorous exercise, or when you drink alcohol or skip meals. These things can influence your glucose levels along with your dose needs can change. Do not change your medication dosage or schedule without the advice of your doctor. Repaglinide is just a portion of a therapy plan which may also incorporate diet, exercise, weight management, blood sugar testing, and medical attention.
Follow your physician’s instructions very carefully. Store repaglinide at room temperature away from moisture and heat.
Side Effects
- constipation
- back pain
- low blood sugar levels
- upper respiratory infections
- headaches
- diarrhea
- muscle pain
Interactions
Repaglinide is metabolized in the liver by an enzyme known as CYP3A4. Drugs that influence this enzyme change its sugar lowering effect and thus may affect the blood levels of repaglinide. The metabolism of repaglinide could be avoided by ketoconazole, itraconazole, fluconazole, erythromycin, and clarithromycin.
Blood levels of repaglinide increase and there is an improved effect. Hypoglycemic reactions could occur. On the other hand, the removal of repaglinide can be raised with drugs that raise levels of CYP3A4 such as barbiturates, carbamazepine, and rifampin. This can result in lower blood levels of repaglinide and hyperglycemia. Blood sugar increases and reverse the effects of repaglinide.
Such medications include diuretics, loop diuretics], amphetamines, glucocorticoids like prednisone and methylprednisolone isoniazid, phenothiazines like chlorpromazine, phenytoin, somatropin, decongestants and thyroid drugs. Anabolic steroids or androgens can boost the chance of developing hypoglycemia in patients taking drugs. The effects of repaglinide can increase and interrupts the opportunity of hypoglycemia. Beta blockers, as an instance, atenolol, propranolol, may cause hypoglycemia or hyperglycemia.
Additionally, beta-blockers can blunt some of their human body’s reactions to hypoglycemia such as rapid heart ratea making it hard for patients to comprehend hypoglycemic reactions. Beta-blockers have been utilized in diabetic patients. Treatment with beta-blockers is correlated with enhanced survival in diabetics who are treated with the beta-blocker for elevated blood pressure.
Gemfibrozil shouldn’t be combined with repaglinide because blood levels of repaglinide may increase and lead to hypoglycemia. The blood levels of repaglinide can raise as well contributing to increased risks of hypoglycemia.