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Rosuvastatin calcium Information
Rosuvastatin is in a group of medications known as HMG CoA reductase inhibitors, or “statins.” Rosuvastatin reduces levels of “bad” cholesterol And triglycerides in the bloodstream, while raising amounts of “good” cholesterol . Rosuvastatin can be used in children and adults who are at least eight years old, to significantly triglycerides and reduce cholesterol From also to impede the accumulation of plaque from blood vessels and the bloodstream.
Rosuvastatin can also be used to reduce the probability of stroke, heart problems, along with other cardiovascular complications in individuals with coronary heart disease, diabetes, along with threat variables.Rosuvastatin can also be used to treat forms including the kind Along with the type that is homozygous . In children who are at least 8 years of age, rosuvastatin may be used for the kind that was heterozygous.
In children as young as seven years of age, rosuvastatin may be utilised for the form. Rosuvastatin might also be utilized for purposes not listed in this medication guide.
Rosuvastatin is a competitive inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA into mevalonate, an ancient rate-limiting step in cholesterol biosynthesis. Rosuvastatin acts primarily from the liver. Decreased hepatic cholesterol levels stimulate the upregulation of hepatic low density lipoprotein (LDL) receptors which raises hepatic uptake of LDL. Rosuvastatin also inhibits hepatic synthesis of very low density lipoprotein (VLDL). The general effect is a decrease in plasma LDL and VLDL.
In vitro and in vivo animal studies also demonstrate that rosuvastatin exerts vasculoprotective effects independent of its lipid-lowering properties. Rosuvastatin exerts an anti-inflammatory effect on rat mesenteric microvascular endothelium by attenuating leukocyte rolling, adherence and transmigration (PMID: 11375257). The medication also modulates nitric oxide synthase (NOS) expression and reduces ischemic-reperfusion accidents in rat hearts (PMID: 15914111). Rosuvastatin increases the bioavailability of nitric oxide (PMID: 11375257, 12031849, 15914111) by upregulating NOS (PMID: 12354446) and by raising the stability of NOS through post-transcriptional polyadenylation (PMID: 17916773). It’s unclear as to how rosuvastatin contributes to these effects though they may be a result of diminished concentrations of mevalonic acid.
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How to use rosuvastatin calcium
Follow all instructions on your prescription label. Your physician may change your dose to make certain you get the best results. Don’t take this medication in smaller or larger amounts or for longer than recommended. Rosuvastatin is usually taken once a day, with or without food. Take the medication. You might need frequent blood tests, when utilizing rosuvastatin.
Keep using this medicine as directed, even in the event you feel good. High cholesterol has no signs. You might need to take rosuvastatin. You might need to quit using rosuvastatin for a short time if you’ve:
- uncontrolled seizures;
- an electrolyte imbalance ;
- severely low blood pressure;
- a serious infection or illness;
- dehydration; or
- surgery or a medical emergency.
You should not quit using rosuvastatin unless your doctor tells you to. Rosuvastatin is a part of a therapy system which may have exercise, diet, and weight management. Follow your physician’s instructions.
Side Effects
- yellowing of your skin or the whites of your eyes
- Liver problems. Your health care professional should do blood tests to check your liver before you start taking rosuvastatin and if you have symptoms of liver problems while you take rosuvastatin. Call your doctor right away if you have any of the following symptoms of liver problems:
- abdominal pain
- upper belly pain
- loss of appetite
- feel unusually tired or weak
- dark urine
- nausea
- headache
- weakness
- muscle aches and pains
- Muscle Problems. Call your health care professional right away if you experience unexplained muscle pain, tenderness, or weakness especially with fever. This may be an early sign of a rare muscle problem that could lead to serious kidney problems. The risk of muscle problems is greater in people who are 65 years of age or older, or who already have thyroid or kidney problems. The chance of muscle problems may be increased if you are taking certain other medicines with rosuvastatin.
Interactions
Seven fold raises when administered together with cyclosporine, and the side effects of rosuvastatin could increase. Rosuvastatin raises the blood thinner warfarin’s action and could raise the chance of bleeding from warfarin. Antacids decrease the absorption of rosuvastatin and should be administered two hours after rosuvastatin. The use of rosuvastatin with nicotinic acid, gemfibrozil or other medications that may induce liver or liver injury might increase the prevalence of this muscle injury.