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Selegiline prevents the breakdown of a chemical in your brain . Low levels of this chemical are related to Parkinson’s disease.Selegiline is used to treat symptoms of Parkinson’s disease.Selegiline may also be used for purposes not listed in this medication guide.
Although the mechanisms for selegiline’s beneficial actions in treating Parkinson’s disease aren’t entirely understood, the selective, irreversible inhibition of monoamine oxidase type B (MAO-B) is believed to be of main importance. MAO-B is included in the oxidative deamination of dopamine within the brain. Selegiline binds to MAO-B inside the nigrostriatal pathways in the central nervous system, thus obstructing microsomal metabolism of dopamine and enhancing the dopaminergic activity in the significant nigra. Selegiline may also increase dopaminergic activity through mechanisms other than inhibition of MAO-B. At higher doses, selegiline can also inhibit monozmine oxidase type A (MAO-A), allowing it to be used for treating depression.
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How to use selegiline
Follow all instructions on your prescription label. Your physician may sometimes change your dose to be certain you find the best outcomes. Don’t use this medication in smaller or bigger quantities or for longer than recommended. Do not change your doses or medication schedule without your doctor’s advice. Capsules are usually taken twice per day, at lunch and breakfast.
Follow the directions of your doctor. The disintegrating tablet form of selegiline Should be taken prior to breakfast and without any liquid. Part of this booklet. As you’re using selegiline, Eating those foods can raise your blood pressure to dangerous levels.
To shoot selegiline orally disintegrating tablets :
- Maintain the tablet in its blister pack until you’re prepared to take the medicine. Open the package and peel back the foil in the blister.
Don’t push a pill through the foil or you may damage the tablet. It will start to dissolve away. Don’t swallow the pill whole. Allow it to dissolve in your mouth. Swallow times as the tablet dissolves.
- Don’t eat or drink anything for at least 5 minutes after carrying a Zelapar orally disintegrating tablet.
Don’t quit taking selegiline abruptly or you might have unwanted side effects.
For optimum results, keep taking the medication. Store this medication at room temperature away from moisture and heat. Maintain each Zelapar tablet from the foil blister pack until you are all set to take it. Throw away any Zelapar tablets.
- Selegiline may worsen your depression, give you suicidal thoughts, or cause unusual changes in behavior. Call your doctor right away if you feel worse with selegiline.
- Selegiline can cause a sudden, large increase in blood pressure (‘‘hypertensive crisis’’) if you eat certain foods and drinks during treatment. See “Drug Precautions”. A hypertensive crisis can lead to stroke and death. Symptoms of a hypertensive crisis include the sudden onset of severe headache, nausea, stiff neck, a fast heartbeat or a change in the way your heart beats (palpitations), a lot of sweating, and confusion. If you suddenly have these symptoms, get medical care right away.
- Selegiline can cause serious and potentially life-threatening reactions if used with certain other medicines. See “Selegiline Drug Precautions”.
- Selegiline can cause low blood pressure. Lie down if you feel dizzy, faint, or lightheaded. Change your position slowly if low blood pressure is a problem for you. Tell your doctor if you have these symptoms. You may need a lower dose of selegiline.
- Selegiline may cause a mental condition called mania or hypomania (mental condition which causes high moods) in people who have a history of mania.