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Azulfidine, Sulfazine
Sulfasalazine Information
Sulfasalazine impacts a chemical within the body that causes inflammation, tissue damage, and diarrhea.Sulfasalazine is used to treat mild to severe gastrointestinal disorders.Sulfasalazine is also utilized to treat rheumatoid arthritis in children and adults who’ve employed other arthritis medicines.Sulfasalazine may also be used for purposes not listed in this medication guide.
The mode of action of Sulfasalazine or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under analysis, but may be related to the anti-inflammatory and/or immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for connective tissue, and/or to the relatively higher concentration it reaches in serous fluids, the liver and intestinal walls, as demonstrated in autoradiographic studies in animals. In ulcerative colitis, clinical trials using rectal administration of Sulfasalazine, SP and 5-ASA have suggested that the major curative action may live from the 5-ASA moiety. The relative contribution of the parent drug as well as the major metabolites in rheumatoid arthritis is unknown.
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How to use sulfasalazine
Follow all instructions. Don’t take this medication in bigger or smaller quantities or for longer than advised. Sulfasalazine could weaken your immune system. Your blood might have to be tested. This medicine can cause results . Take this medicine after a meal. Do not crush, chew, or break an coated tablet. Swallow it whole. The pill has a special coating. By breaking the pill, this coating will be damaged. For optimum results, keep using this medication as directed.
Sulfasalazine won’t cure ulcerative colitis, but it can lower the amount. If you are currently treating arthritis, don’t quit using any of the other arthritis medications until your physician tells you to. Your symptoms may not change immediately once you begin taking sulfasalazine, and you may still want your other medicines for awhile. Store at room temperature away from moisture and heat.
Side Effects
- headache
- diarrhea
- stomach pain
- upset stomach
- vomiting
- loss of appetite
Interactions
Sulfasalazine can cause reduced absorption of digoxin and folic acid . Reduced acid absorption might cause folic acid deficiency also result. Reduced digoxin absorption may lessen the efficacy of digoxin. Sulfapyridine is a sulfonamide, and sulfonamides increase blood levels of methotrexate , resulting in increased methotrexate toxicity. Conversely, methotrexate can raise the occurrence of the anemia brought on by sulfonamides since folic acid deficiency is additionally caused by methotrexate.
Sulfonamides can increase the risk of kidney damage from cyclosporine via an unidentified mechanism. They potentially cause excessive reductions by elevating the amount of the medication in the bloodstream and also decreasing removal of medications and might increase the blood glucose lowering effect of drugs. Combining 5-ASA with drugs that affect kidney function like nonsteroidal antiinflammatory drugs, for example, aspirin may increase the likelihood of kidney dysfunction.
Concurrent use of 5-ASA and 6-mercaptopurine or azathioprine may raise the likelihood of blood ailments. 5-ASA may increase the blood .