Sumatriptan Succinate

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Brand Names
Alsuma, Imitrex, Onzetra Xsail, Sumavel DosePro, Treximet, Zecuity, Zembrace SymTouch

Sumatriptan succinate Information

Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces chemicals in the body that may trigger headache nausea, pain, sensitivity to light and sound, and other migraine symptoms.Sumatriptan is used to treat migraine headaches and cluster headaches in adults. Sumatriptan will just deal with.

It won’t stop headaches or reduce the amount of attacks.Sumatriptan shouldn’t be used to treat a headache which leads to loss of motion or a frequent tension headache. Use this medication only if your condition was confirmed by a doctor as pain.Sumatriptan may also be used for purposes not listed in this medication guide.

Used for treatment: Migraine, Acute, Acute Cluster headaches

The 5-HT1B and 5-HT1D receptors function as autoreceptors, which inhibit the firing of serotonin neurons along with a decrease in the synthesis and release of dopamine upon regeneration. After sumatriptan binds to these receptors, adenylate cyclase activity is inhibited via regulatory G proteins, incrases intracellular calcium, and affects other intracellular occasions. This causes vasoconstriction and inhibtion of sensory nociceptive (trigeminal) nerve shooting and vasoactive neuropeptide release.

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How to use sumatriptan succinate

Adhere to all directions on your prescription label. Do not take this medication in smaller or larger amounts or for longer than advised.

Side Effects

  • unusual or bad taste in your mouth
  • stomach pain after meals
  • tingling or numbness in your fingers or toes
  • changes in color or sensation in your fingers and toes (Raynaud’s syndrome)
  • feeling weak, drowsy, or tired
  • dizziness
  • warm, hot, burning feeling to your face (flushing)
  • problems with blood circulation to your legs and feet (peripheral vascular ischemia). Symptoms of peripheral vascular ischemia include:
    • cramping and pain in your legs or hips
    • dizziness
    • constipation or diarrhea
    • feeling of heaviness or tightness in your leg muscles
    • stomach and intestinal problems (gastrointestinal and colonic ischemic events). Symptoms of gastrointestinal and colonic ischemic events include:
      • sudden or severe stomach pain
      • cold feeling or color changes in 1 or both legs or feet
      • discomfort or stiffness in your neck
      • dizziness
      • sensitivity to loud noises
      • bloody diarrhea
      • feeling weak, drowsy, or tired
      • fever
      • medication overuse headaches. Some people who take/use too much sumatriptan may have worse headaches (medication overuse headache). If your headaches get worse, your healthcare provider may decide to stop your treatment with sumatriptan.
      • tingling or numbness in your fingers or toes
      • injection site reactions such as redness, pain, or swelling
      • burning or aching pain in your feet or toes while resting
      • feeling weak, drowsy, or tired
      • discomfort of your neck, throat, or nose
      • weight loss
      • numbness, tingling, or weakness in your legs
      • warm, hot, burning feeling to your face (flushing)
      • nausea or vomiting
      • hives (itchy bumps); swelling of your tongue, mouth, or throat
      • warm, hot, burning feeling to your face (flushing)


      Monoamine oxidase inhibitors or MAOIs, for example may reduce sumatriptan’s breakdown leading to increased blood levels and side effects of sumatriptan. Mixing sumatriptan using sibutramine, selective serotonin reuptake inhibitors or SSRIs, such as fluoxetine, citalopram , paroxetine, and sertraline or serotonin and norepinephrine reuptake inhibitors, including venlafaxine, duloxetine , and desvenlafaxine may increase the concentration of dopamine in the brain, causing increased serotonin-related unwanted effects.

      Because combinations increase the likelihood of vasospasms administering sumatriptan within 24 hours of treatment is contraindicated.