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Tenivastatin sodium Information
Simvastatin is in a group of drugs known as HMG CoA reductase inhibitors, or “statins.” Simvastatin reduces levels of “bad” cholesterol And triglycerides in the blood, while raising levels of “good” cholesterol . Simvastatin is used to lower triglycerides and cholesterol In the blood. Simvastatin is utilised to reduce the probability of heart problems stroke, and other heart complications in individuals with coronary heart disease, diabetes, or threat factors.Simvastatin can be used in kids and adults that are at least 10 years old.Simvastatin may also be used for purposes not listed in this medication guide.
Simvastatin is a prodrug where the 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate the beta,delta-dihydroxy acid, an active metabolite structurally like HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme lowers the number of mevalonic acid, a precursor of cholesterol.
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How to use tenivastatin sodium
Follow all directions. Never take this medicine in larger amounts, or for longer than prescribed. Life-threatening or serious unwanted effects may be caused by taking too much of the medication. Simvastatin is normally taken at bedtime or with an evening supper. Should you take simvastatin daily, take it. Your doctor may change your dose to make sure you receive the best results. When using simvastatin, you might need frequent blood tests at your doctor’s office.
You might need to take simvastatin to a long-term basis for treating high cholesterol. When you have surgery or even a medical crisis, you might need to quit using simvastatin. Don’t stop taking this medicine unless your doctor tells you to. Simvastatin is only a part of a complete application of therapy which also includes exercise, diet, and weight control. Store at room temperature away from lighting, heat, and moisture.
Side Effects
- headache
- nausea
- stomach pain
- constipation
- upper airway infections
- muscle and joint aches
Interactions
Removal of simvastatin increase the risk of muscle toxicity and can increase the degree of simvastatin from the human body. Examples contain erythromycin, ketoconazole, itraconazole, clarithromycin, telithromycin, cyclosporine, nefazodone, boceprevir, telaprevir, voriconazole, posaconazole, and HIV protease inhibitors such as: indinavir and ritonavir.
They should not be combined with simvastatin. Blood levels of simvastatin can also increase and should be prevented. These drugs shouldn’t be used with simvastatin: Amiodarone, verapamil, diltiazem, amlodipine, danazol, ranolazine, niacin, gemfibrozil and fenofibrate. Patients taking amiodarone, amlodipine, or ranolazine shouldn’t exceed 20 mg, and patients taking diltiazem or verapamil shouldn’t exceed 10 mg of of simvastatin daily.
Patients taking danazol or gemfibrozil should not take simvastatin. Simvastatin increases the effect of warfarin and digoxin’s blood concentration. Patients taking simvastatin and warfarin or digoxin ought to be monitored carefully. Cholestyramine decreases the absorption of ezetimibe; thus, simvastatin ought to be taken 2 hours before or at least 4 hours. Chinese patients taking